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Hydroxychloroquine and chloroquine: a potential and controversial treatment for COVID-19.
Zou, Li; Dai, Lijun; Zhang, Xingyu; Zhang, Zhaohui; Zhang, Zhentao.
  • Zou L; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
  • Dai L; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
  • Zhang X; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
  • Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. zhzhqing1990@163.com.
  • Zhang Z; Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. zhentaozhang@whu.edu.cn.
Arch Pharm Res ; 43(8): 765-772, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-692878
ABSTRACT
A novel coronavirus, later named SARS-CoV-2, was first reported in China in December 2019 and subsequently widely identified in the United States, Japan, South Korea, France, India, and other countries. The disease caused by SARS-CoV-2 infection was called COVID-19. The high fatality and morbidity rates of COVID-19 make it the third largest global epidemic in this century. However, there are currently no approved antiviral drugs for the COVID-19 treatment. Recently, two old antimalarial drugs, hydroxychloroquine and chloroquine, have been found to exert anti-SARS-CoV-2 effects both in vitro and in vivo. Preliminary clinical evidence suggests these drugs may have an effect on the treatment of COVID-19. Herein, we review the pharmacokinetics characteristics and antiviral effects of these drugs, in addition to their side effects and clinical evidence of their use for the COVID-19 treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Chloroquine / Coronavirus Infections / Hydroxychloroquine Type of study: Prognostic study Limits: Humans Language: English Journal: Arch Pharm Res Year: 2020 Document Type: Article Affiliation country: S12272-020-01258-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Chloroquine / Coronavirus Infections / Hydroxychloroquine Type of study: Prognostic study Limits: Humans Language: English Journal: Arch Pharm Res Year: 2020 Document Type: Article Affiliation country: S12272-020-01258-7