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Clinical Course and Outcomes of 3,060 Patients with Coronavirus Disease 2019 in Korea, January-May 2020.
Sung, Ho Kyung; Kim, Jin Yong; Heo, Jeonghun; Seo, Haesook; Jang, Young Soo; Kim, Hyewon; Koh, Bo Ram; Jo, Neungsun; Oh, Hong Sang; Baek, Young Mi; Park, Kyung Hwa; Shon, Jeung A; Kim, Min Chul; Kim, Joon Ho; Chang, Hyun Ha; Park, Yukyung; Kang, Yu Min; Lee, Dong Hyun; Oh, Dong Hyun; Park, Hyun Jung; Song, Kyoung Ho; Lee, Eun Kyoung; Jeong, Hyeongseok; Lee, Ji Yeon; Ko, Ja Young; Choi, Jihee; Ryu, Eun Hwa; Chung, Ki Hyun; Oh, Myoung Don.
  • Sung HK; National Emergency Medical Center, National Medical Center, Seoul, Korea.
  • Kim JY; Division of Infectious Diseases, Department of Internal Medicine, Incheon Medical Center, Incheon, Korea.
  • Heo J; Department of Pulmonology, Busan Medical Center, Busan, Korea.
  • Seo H; Department of Tuberculosis, Seoul Metropolitan Seobuk Hospital, Seoul, Korea.
  • Jang YS; Department of Orthopedic Surgery, Seoul Metropolitan Seonam Hospital, Seoul, Korea.
  • Kim H; Department of Laboratory Medicine, Chungju Medical Center, Chungju, Korea.
  • Koh BR; Department of Internal Medicine, Gyeonggi Provincial Medical Center Ansung Hospital, Anseong, Korea.
  • Jo N; Department of Infection Control, Chungcheongnam-do Gongju Medical Center, Gongju, Korea.
  • Oh HS; Division of Infectious Disease, Department of Internal Medicine, Armed Forces Capital Hospital, Seongnam, Korea.
  • Baek YM; Department of Infection Control, Chungcheongnam-do Seosan Medical Center, Seosan, Korea.
  • Park KH; Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Korea.
  • Shon JA; Department of Nursing, Yeongju Red Cross Hospital, Yeongju, Korea.
  • Kim MC; Division of Infectious Diseases, Department of Internal Medicine, Chung-Ang University Hospital, Seoul, Korea.
  • Kim JH; Department of Surgery, Gyeonggi Provincial Medical Center Uijeongbu Hospital, Uijeongbu, Korea.
  • Chang HH; Division of Infectious Disease, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea.
  • Park Y; Department of Internal Medicine, Korea Workers' Compensation & Welfare Services Daegu Hospital, Daegu, Korea.
  • Kang YM; Division of Infectious Diseases, Department of Internal Medicine, Myongji Hospital, Goyang, Korea.
  • Lee DH; Department of Internal Medicine, Chungcheongnam-do Cheonan Medical Center, Cheonan, Korea.
  • Oh DH; Division of Infectious Diseases, Department of Internal Medicine, Seoul Medical Center, Seoul, Korea.
  • Park HJ; Department of Internal Medicine, Jeonllanam-do Suncheon Medical Center, Suncheon, Korea.
  • Song KH; Division of Infectious Diseases, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
  • Lee EK; Infection Control Team, Cheongju Medical Center, Cheongju, Korea.
  • Jeong H; Division of Infectious Diseases, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Korea.
  • Lee JY; Division of Infectious Diseases, Department of Internal Medicine, Keimyung University Dongsan Hospital, Daegu, Korea.
  • Ko JY; Intensive Care Team, Gyeonggi Provincial Medical Center Paju Hospital, Paju, Korea.
  • Choi J; Infection Control Team, Gyeonggi Provincial Medical Center Icheon Hospital, Icheon, Korea.
  • Ryu EH; Infection Control Team, Korea Worker's Compensation & Welfare Service Changwon Hospital, Changwon, Korea.
  • Chung KH; National Medical Center, Seoul, Korea.
  • Oh MD; Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea. mdohmd@snu.ac.kr.
J Korean Med Sci ; 35(30): e280, 2020 Aug 03.
Article in English | MEDLINE | ID: covidwho-693314
ABSTRACT

BACKGROUND:

The fatality rate of patients with coronavirus disease 2019 (COVID-19) varies among countries owing to demographics, patient comorbidities, surge capacity of healthcare systems, and the quality of medical care. We assessed the clinical outcomes of patients with COVID-19 during the first wave of the epidemic in Korea.

METHODS:

Using a modified World Health Organization clinical record form, we obtained clinical data for 3,060 patients with COVID-19 treated at 55 hospitals in Korea. Disease severity scores were defined as 1) no limitation of daily activities; 2) limitation of daily activities but no need for supplemental oxygen; 3) supplemental oxygen via nasal cannula; 4) supplemental oxygen via facial mask; 5) non-invasive mechanical ventilation; 6) invasive mechanical ventilation; 7) multi-organ failure or extracorporeal membrane oxygenation therapy; and 8) death. Recovery was defined as a severity score of 1 or 2, or discharge and release from isolation.

RESULTS:

The median age of the patients was 43 years of age; 43.6% were male. The median time from illness onset to admission was 5 days. Of the patients with a disease severity score of 3-4 on admission, 65 (71.5%) of the 91 patients recovered, and 7 (7.7%) died due to illness by day 28. Of the patients with disease severity scores of 5-7, 7 (19.5%) of the 36 patients recovered, and 8 (22.2%) died due to illness by day 28. None of the 1,324 patients who were < 50 years of age died; in contrast, the fatality rate due to illness by day 28 was 0.5% (2/375), 0.9% (2/215), 5.8% (6/104), and 14.0% (7/50) for the patients aged 50-59, 60-69, 70-79, and ≥ 80 years of age, respectively.

CONCLUSION:

In Korea, almost all patients of < 50 years of age with COVID-19 recovered without supplemental oxygen. In patients of ≥ 50 years of age, the fatality rate increased with age, reaching 14% in patients of ≥ 80 years of age.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Korean Med Sci Journal subject: Medicine Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Korean Med Sci Journal subject: Medicine Year: 2020 Document Type: Article