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COVID-19 and comorbidities: Deleterious impact on infected patients.
Ejaz, Hasan; Alsrhani, Abdullah; Zafar, Aizza; Javed, Humera; Junaid, Kashaf; Abdalla, Abualgasim E; Abosalif, Khalid O A; Ahmed, Zeeshan; Younas, Sonia.
  • Ejaz H; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia. Electronic address: hetariq@ju.edu.sa.
  • Alsrhani A; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia.
  • Zafar A; Microbiology Department, The Children's Hospital and The Institute of Child Health, Lahore, Pakistan.
  • Javed H; Microbiology Department, The Children's Hospital and The Institute of Child Health, Lahore, Pakistan.
  • Junaid K; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia.
  • Abdalla AE; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia; Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan.
  • Abosalif KOA; Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Al Jouf, Saudi Arabia; Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan.
  • Ahmed Z; Institute of Industrial Biotechnology, GC University, Lahore 5400, Pakistan.
  • Younas S; Department of Pathology, Tehsil Headquarter Hospital Kamoke, District Gujranwala, Pakistan.
J Infect Public Health ; 13(12): 1833-1839, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-1023643
ABSTRACT
The pandemic situation with the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from China has endangered human lives. Coronavirus disease 2019 (COVID-19) is presented with asymptomatic, mild, or severe pneumonia-like symptoms. COVID-19 patients with diabetes, chronic obstructive pulmonary disease (COPD), cardiovascular diseases (CVD), hypertension, malignancies, HIV, and other comorbidities could develop a life-threatening situation. SARS-CoV-2 utilizes ACE-2 receptors found at the surface of the host cells to get inside the cell. Certain comorbidities are associated with a strong ACE-2 receptor expression and higher release of proprotein convertase that enhances the viral entry into the host cells. The comorbidities lead to the COVID-19 patient into a vicious infectious circle of life and are substantially associated with significant morbidity and mortality. The comorbid individuals must adopt the vigilant preventive measure and require scrupulous management. In this review, we rigorously focused on the impact of common morbidities in COVID-19 patients and recapitulated the management strategies with recent directions. We found limited resources describing the association of comorbidities in COVID-19; however, our review delineates the broader spectrum of comorbidities with COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies Topics: Long Covid Limits: Humans Language: English Journal: J Infect Public Health Journal subject: Communicable Diseases / Public Health Year: 2020 Document Type: Article