Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2-Infected Macaques.
J Infect Dis
; 222(10): 1596-1600, 2020 10 13.
Article
in English
| MEDLINE | ID: covidwho-693639
ABSTRACT
Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Lung Diseases, Interstitial
/
Coronavirus Infections
/
Disease Models, Animal
/
Betacoronavirus
/
Lymphopenia
/
Monkey Diseases
Topics:
Long Covid
Limits:
Animals
Language:
English
Journal:
J Infect Dis
Year:
2020
Document Type:
Article
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