Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19.
Acta Pharmacol Sin
; 41(9): 1141-1149, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-694139
ABSTRACT
Coronavirus disease 2019 is a newly emerging infectious disease currently spreading across the world. It is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The spike (S) protein of SARS-CoV-2, which plays a key role in the receptor recognition and cell membrane fusion process, is composed of two subunits, S1 and S2. The S1 subunit contains a receptor-binding domain that recognizes and binds to the host receptor angiotensin-converting enzyme 2, while the S2 subunit mediates viral cell membrane fusion by forming a six-helical bundle via the two-heptad repeat domain. In this review, we highlight recent research advance in the structure, function and development of antivirus drugs targeting the S protein.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Antiviral Agents
/
Pneumonia, Viral
/
Coronavirus Infections
/
Virus Internalization
/
Pandemics
/
Spike Glycoprotein, Coronavirus
/
Betacoronavirus
Limits:
Humans
Language:
English
Journal:
Acta Pharmacol Sin
Journal subject:
Pharmacology
Year:
2020
Document Type:
Article
Affiliation country:
S41401-020-0485-4
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