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Safety and COVID-19 Symptoms in Individuals Recently Vaccinated with BCG: a Retrospective Cohort Study.
Moorlag, Simone J C F M; van Deuren, Rosanne C; van Werkhoven, Cornelis H; Jaeger, Martin; Debisarun, Priya; Taks, Esther; Mourits, Vera P; Koeken, Valerie A C M; de Bree, L Charlotte J; Ten Doesschate, Thijs; Cleophas, Maartje C; Smeekens, Sanne; Oosting, Marije; van de Veerdonk, Frank L; Joosten, Leo A B; Ten Oever, Jaap; van der Meer, Jos W M; Curtis, Nigel; Aaby, Peter; Stabell-Benn, Christine; Giamarellos-Bourboulis, Evangelos J; Bonten, Marc; van Crevel, Reinout; Netea, Mihai G.
  • Moorlag SJCFM; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • van Deuren RC; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • van Werkhoven CH; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Jaeger M; The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Debisarun P; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Taks E; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Mourits VP; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Koeken VACM; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • de Bree LCJ; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Ten Doesschate T; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Cleophas MC; Danish Institute for Advanced Study, University of Southern Denmark, Denmark.
  • Smeekens S; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Odense, Denmark.
  • Oosting M; The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • van de Veerdonk FL; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Joosten LAB; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Ten Oever J; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • van der Meer JWM; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Curtis N; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Aaby P; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Stabell-Benn C; Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
  • Giamarellos-Bourboulis EJ; Department of Paediatrics, The University of Melbourne; and Murdoch Children's Research Institute, Royal Children's Hospital Melbourne, Parkville, VIC 3052, Australia.
  • Bonten M; Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.
  • van Crevel R; Danish Institute for Advanced Study, University of Southern Denmark, Denmark.
  • Netea MG; OPEN, Institute of Clinical Research, University of Southern Denmark/Odense University Hospital, Odense, Denmark.
Cell Rep Med ; 1(5): 100073, 2020 08 25.
Article in English | MEDLINE | ID: covidwho-694416
ABSTRACT
Bacille Calmette-Guérin (BCG) induces long-term boosting of innate immunity, termed trained immunity, and decreases susceptibility to respiratory tract infections. BCG vaccination trials for reducing SARS-CoV-2 infection are underway, but concerns have been raised regarding the potential harm of strong innate immune responses. To investigate the safety of BCG vaccination, we retrospectively assessed coronavirus disease 2019 (COVID-19) and related symptoms in three cohorts of healthy volunteers who either received BCG in the last 5 years or did not. BCG vaccination is not associated with increased incidence of symptoms during the COVID-19 outbreak in the Netherlands. Our data suggest that BCG vaccination might be associated with a decrease in the incidence of sickness during the COVID-19 pandemic (adjusted odds ratio [AOR] 0.58, p < 0.05), and lower incidence of extreme fatigue. In conclusion, recent BCG vaccination is safe, and large randomized trials are needed to reveal if BCG reduces the incidence and/or severity of SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / Vaccination / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: Cell Rep Med Year: 2020 Document Type: Article Affiliation country: J.xcrm.2020.100073

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Full text: Available Collection: International databases Database: MEDLINE Main subject: BCG Vaccine / Vaccination / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid / Vaccines Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Country/Region as subject: Europa Language: English Journal: Cell Rep Med Year: 2020 Document Type: Article Affiliation country: J.xcrm.2020.100073