Your browser doesn't support javascript.
Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.
Rodriguez, Lucie; Pekkarinen, Pirkka T; Lakshmikanth, Tadepally; Tan, Ziyang; Consiglio, Camila Rosat; Pou, Christian; Chen, Yang; Mugabo, Constantin Habimana; Nguyen, Ngoc Anh; Nowlan, Kirsten; Strandin, Tomas; Levanov, Lev; Mikes, Jaromir; Wang, Jun; Kantele, Anu; Hepojoki, Jussi; Vapalahti, Olli; Heinonen, Santtu; Kekäläinen, Eliisa; Brodin, Petter.
  • Rodriguez L; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Pekkarinen PT; Division of Intensive Care Medicine, Department of Anesthesiology, Intensive Care and Pain Medicine, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Lakshmikanth T; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Tan Z; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Consiglio CR; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Pou C; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Chen Y; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Mugabo CH; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Nguyen NA; Translational Immunology Research Program, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Nowlan K; Translational Immunology Research Program, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Strandin T; Department of Virology, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Levanov L; Department of Virology, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Mikes J; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Wang J; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
  • Kantele A; Inflammation Center, Division of Infectious Diseases, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Hepojoki J; Department of Virology, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Vapalahti O; Department of Virology, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Heinonen S; New Children's Hospital, Pediatric Research Center, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Kekäläinen E; Translational Immunology Research Program, University of Helsinki, and Helsinki University Hospital, Helsinki 00100, Finland.
  • Brodin P; Science for Life Laboratory, Department of Women's and Children's Health, Karolinska Institutet, Solna 171 77, Sweden.
Cell Rep Med ; 1(5): 100078, 2020 08 25.
Article in English | MEDLINE | ID: covidwho-694586
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
Severe disease of SARS-CoV-2 is characterized by vigorous inflammatory responses in the lung, often with a sudden onset after 5-7 days of stable disease. Efforts to modulate this hyperinflammation and the associated acute respiratory distress syndrome rely on the unraveling of the immune cell interactions and cytokines that drive such responses. Given that every patient is captured at different stages of infection, longitudinal monitoring of the immune response is critical and systems-level analyses are required to capture cellular interactions. Here, we report on a systems-level blood immunomonitoring study of 37 adult patients diagnosed with COVID-19 and followed with up to 14 blood samples from acute to recovery phases of the disease. We describe an IFNγ-eosinophil axis activated before lung hyperinflammation and changes in cell-cell co-regulation during different stages of the disease. We also map an immune trajectory during recovery that is shared among patients with severe COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Cell Rep Med Year: 2020 Document Type: Article Affiliation country: J.xcrm.2020.100078

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Cohort study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: Cell Rep Med Year: 2020 Document Type: Article Affiliation country: J.xcrm.2020.100078