Therapeutic options of TCM for organ injuries associated with COVID-19 and the underlying mechanism.
Phytomedicine
; 85: 153297, 2021 May.
Article
in English
| MEDLINE | ID: covidwho-694859
ABSTRACT
BACKGROUND:
Coronavirus disease-2019 (COVID-19) caused by infection with severe acute respiratory coronavirus-2 (SARS-CoV-2) has been spreading rapidly throughout China and in other countries since the end of 2019. The World Health Organization (WHO) has declared that the epidemic is a public health emergency of international concerns. The timely and appropriate measures for treating COVID-19 in China, which are inseparable from the contribution of traditional Chinese medicine (TCM), have won much praise of the world.PURPOSE:
This review aimed to summarize and discuss the essential role of TCM in protecting tissues from injuries associated with COVID-19, and accordingly to clarify the possible action mechanisms of TCM from the perspectives of anti-inflammatory, antioxidant and anti-apoptotic effects.METHODS:
Electronic databases such as Pubmed, ResearchGate, Science Direct, Web of Science, medRixv and Wiley were used to search scientific literatures.RESULTS:
The present review found that traditional Chinese herbs commonly used for the clinical treatment of organ damages caused by COVID-19, such as Scutellaria baicalensis, Salvia miltiorrhizaSalvia miltiorrhiza, and ginseng, could act on multiple signaling pathways involved in inflammation, oxidative stress and apoptosis.CONCLUSION:
TCM could protect COVID-19 patients from tissue injuries, a protection that might be, at least partially, attributed to the anti-inflammatory, antioxidant and anti-apoptotic effects of the TCM under investigation. This review provides evidence and support for clinical treatment and novel drug research using TCM.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Drugs, Chinese Herbal
/
COVID-19 Drug Treatment
/
Medicine, Chinese Traditional
Type of study:
Prognostic study
/
Reviews
Topics:
Traditional medicine
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
Phytomedicine
Journal subject:
Complementary Therapies
Year:
2021
Document Type:
Article
Affiliation country:
J.phymed.2020.153297
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