MECHANISMS IN ENDOCRINOLOGY: Vitamin D and COVID-19.
Eur J Endocrinol
; 183(5): R133-R147, 2020 Nov.
Article
in English
| MEDLINE | ID: covidwho-695333
ABSTRACT
The SARS-CoV-2 virus responsible for the COVID-19 pandemic has generated an explosion of interest both in the mechanisms of infection leading to dissemination and expression of this disease, and in potential risk factors that may have a mechanistic basis for disease propagation or control. Vitamin D has emerged as a factor that may be involved in these two areas. The focus of this article is to apply our current understanding of vitamin D as a facilitator of immunocompetence both with regard to innate and adaptive immunity and to consider how this may relate to COVID-19 disease. There are also intriguing potential links to vitamin D as a factor in the cytokine storm that portends some of the most serious consequences of SARS-CoV-2 infection, such as the acute respiratory distress syndrome. Moreover, cardiac and coagulopathic features of COVID-19 disease deserve attention as they may also be related to vitamin D. Finally, we review the current clinical data associating vitamin D with SARS-CoV-2 infection, a putative clinical link that at this time must still be considered hypothetical.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Vitamin D
/
T-Lymphocytes
/
Coronavirus Infections
/
Adaptive Immunity
/
Cytokine Release Syndrome
/
Immunity, Innate
/
Immunocompetence
/
Lung
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Eur J Endocrinol
Journal subject:
Endocrinology
Year:
2020
Document Type:
Article
Affiliation country:
EJE-20-0665
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