Features of severe COVID-19: A systematic review and meta-analysis.
Eur J Clin Invest
; 50(10): e13378, 2020 Oct.
Article
in English
| MEDLINE | ID: covidwho-695540
ABSTRACT
BACKGROUND:
To systematically review clinical and biochemical characteristics associated with the severity of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related disease (COVID-19). MATERIALS ANDMETHODS:
Systematic review of observational studies from PubMed, ISI Web of Science, SCOPUS and Cochrane databases including people affected by COVID-19 and reporting data according to the severity of the disease. Data were combined with odds ratio (OR) and metanalysed. Severe COVID-19 was defined by acute respiratory distress syndrome, intensive care unit admission and death.RESULTS:
We included 12 studies with 2794 patients, of whom 596 (21.33%) had severe disease. A slightly higher age was found in severe vs non-severe disease. We found that prevalent cerebrovascular disease (odds ratio [OR] 3.66, 95% confidence interval [CI] 1.73-7.72), chronic obstructive pulmonary disease (OR 2.39, 95% CI 1.10-5.19), prevalent cardiovascular disease (OR 2.84, 95% CI 1.59-5.10), diabetes (OR 2.78, 95% CI 2.09-3.72), hypertension (OR 2.24, 95% CI 1.63-3.08), smoking (OR 1.54, 95% CI 1.07-2.22) and male sex (OR 1.22, 95% CI 1.01-1.49) were associated with severe disease. Furthermore, increased procalcitonin (OR 8.21, 95% CI 4.48-15.07), increased D-Dimer (OR 5.67, 95% CI 1.45-22.16) and thrombocytopenia (OR 3.61, 95% CI 2.62-4.97) predicted severe infection.CONCLUSION:
Characteristics associated with the severity of SARS-CoV-2 infection may allow an early identification and management of patients with poor outcomes.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Thrombocytopenia
/
Fibrin Fibrinogen Degradation Products
/
Cardiovascular Diseases
/
Smoking
/
Coronavirus Infections
/
Pulmonary Disease, Chronic Obstructive
/
Diabetes Mellitus
/
Procalcitonin
Type of study:
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Humans
Language:
English
Journal:
Eur J Clin Invest
Year:
2020
Document Type:
Article
Affiliation country:
Eci.13378
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