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Management of epigenomic networks entailed in coronavirus infections and COVID-19.
El Baba, Ranim; Herbein, Georges.
  • El Baba R; Department Pathogens & Inflammation-EPILAB, UPRES EA4266, University of Franche-Comté and University of Bourgogne Franche-Comté, F-25030, Besançon, France.
  • Herbein G; Université Libanaise, Beirut, Lebanon.
Clin Epigenetics ; 12(1): 118, 2020 08 05.
Article in English | MEDLINE | ID: covidwho-695596
ABSTRACT
Coronaviruses (CoVs) are highly diverse single-stranded RNA viruses owing to their susceptibility to numerous genomic mutations and recombination. Such viruses involve human and animal pathogens including the etiologic agents of acute respiratory tract illnesses severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and the highly morbific SARS-CoV-2. Coronavirus disease 2019 (COVID-19), an emerging disease with a quick rise in infected cases and deaths, was recently identified causing a worldwide pandemic. COVID-19 disease outcomes were found to increase in elderly and patients with a compromised immune system. Evidences indicated that the main culprit behind COVID-19 deaths is the cytokine storm, which is illustrated by an uncontrolled over-production of soluble markers of inflammation. The regulation process of coronavirus pathogenesis through molecular mechanism comprise virus-host interactions linked to viral entry, replication and transcription, escape, and immune system control. Recognizing coronavirus infections and COVID-19 through epigenetics lens will lead to potential alteration in gene expression thus limiting coronavirus infections. Focusing on epigenetic therapies reaching clinical trials, clinically approved epigenetic-targeted agents, and combination therapy of antivirals and epigenetic drugs is currently considered an effective and valuable approach for viral replication and inflammatory overdrive control.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Epigenomics / Pandemics / Betacoronavirus Type of study: Etiology study / Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Epigenetics Year: 2020 Document Type: Article Affiliation country: S13148-020-00912-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Epigenomics / Pandemics / Betacoronavirus Type of study: Etiology study / Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Epigenetics Year: 2020 Document Type: Article Affiliation country: S13148-020-00912-7