Your browser doesn't support javascript.
Semantic information from SemMedBD (by NLM)
1. Shock PROCESS_OF Child
Subject
Shock
Predicate
PROCESS_OF
Object
Child
2. Symptoms ASSOCIATED_WITH COVID-19
Subject
Symptoms
Predicate
ASSOCIATED_WITH
Object
COVID-19
3. Virus CAUSES COVID-19
Subject
Virus
Predicate
CAUSES
Object
COVID-19
4. Symptoms COEXISTS_WITH Fever
Subject
Symptoms
Predicate
COEXISTS_WITH
Object
Fever
5. Sign or Symptom COEXISTS_WITH Fever
Subject
Sign or Symptom
Predicate
COEXISTS_WITH
Object
Fever
6. Conjunctivitis PREDISPOSES Inflammation
Subject
Conjunctivitis
Predicate
PREDISPOSES
Object
Inflammation
7. Anaplastic Sarcoma of the Kidney PROCESS_OF Clinician
Subject
Anaplastic Sarcoma of the Kidney
Predicate
PROCESS_OF
Object
Clinician
8. Shock COEXISTS_WITH Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Subject
Shock
Predicate
COEXISTS_WITH
Object
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
9. Severe clinical course PROCESS_OF Patients
Subject
Severe clinical course
Predicate
PROCESS_OF
Object
Patients
10. Symptoms PROCESS_OF Offspring
Subject
Symptoms
Predicate
PROCESS_OF
Object
Offspring
11. Awareness PROCESS_OF Offspring
Subject
Awareness
Predicate
PROCESS_OF
Object
Offspring
12. Shock PROCESS_OF Child
Subject
Shock
Predicate
PROCESS_OF
Object
Child
13. Symptoms ASSOCIATED_WITH COVID-19
Subject
Symptoms
Predicate
ASSOCIATED_WITH
Object
COVID-19
14. Virus CAUSES COVID-19
Subject
Virus
Predicate
CAUSES
Object
COVID-19
15. Symptoms COEXISTS_WITH Fever
Subject
Symptoms
Predicate
COEXISTS_WITH
Object
Fever
16. Sign or Symptom COEXISTS_WITH Fever
Subject
Sign or Symptom
Predicate
COEXISTS_WITH
Object
Fever
17. Conjunctivitis PREDISPOSES Inflammation
Subject
Conjunctivitis
Predicate
PREDISPOSES
Object
Inflammation
18. Anaplastic Sarcoma of the Kidney PROCESS_OF Clinician
Subject
Anaplastic Sarcoma of the Kidney
Predicate
PROCESS_OF
Object
Clinician
19. Shock COEXISTS_WITH Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Subject
Shock
Predicate
COEXISTS_WITH
Object
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
20. Severe clinical course PROCESS_OF Patients
Subject
Severe clinical course
Predicate
PROCESS_OF
Object
Patients
21. Symptoms PROCESS_OF Offspring
Subject
Symptoms
Predicate
PROCESS_OF
Object
Offspring
22. Awareness PROCESS_OF Offspring
Subject
Awareness
Predicate
PROCESS_OF
Object
Offspring
ABSTRACT
In April 2020, during the peak of the coronavirus disease 2019 (COVID-19) pandemic in Europe, a cluster of children with hyperinflammatory shock with features similar to Kawasaki disease and toxic shock syndrome was reported in England* (1). The patients' signs and symptoms were temporally associated with COVID-19 but presumed to have developed 2-4 weeks after acute COVID-19; all children had serologic evidence of infection with SARS-CoV-2, the virus that causes COVID-19 (1). The clinical signs and symptoms present in this first cluster included fever, rash, conjunctivitis, peripheral edema, gastrointestinal symptoms, shock, and elevated markers of inflammation and cardiac damage (1). On May 14, 2020, CDC published an online Health Advisory that summarized the manifestations of reported multisystem inflammatory syndrome in children (MIS-C), outlined a case definition,† and asked clinicians to report suspected U.S. cases to local and state health departments. As of July 29, a total of 570 U.S. MIS-C patients who met the case definition had been reported to CDC. A total of 203 (35.6%) of the patients had a clinical course consistent with previously published MIS-C reports, characterized predominantly by shock, cardiac dysfunction, abdominal pain, and markedly elevated inflammatory markers, and almost all had positive SARS-CoV-2 test results. The remaining 367 (64.4%) of MIS-C patients had manifestations that appeared to overlap with acute COVID-19 (2-4), had a less severe clinical course, or had features of Kawasaki disease.§ Median duration of hospitalization was 6 days; 364 patients (63.9%) required care in an intensive care unit (ICU), and 10 patients (1.8%) died. As the COVID-19 pandemic continues to expand in many jurisdictions, clinicians should be aware of the signs and symptoms of MIS-C and report suspected cases to their state or local health departments; analysis of reported cases can enhance understanding of MIS-C and improve characterization of the illness for early detection and treatment.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Systemic Inflammatory Response Syndrome Type of study: Observational study / Prognostic study Topics: Long Covid / Variants Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: North America Language: English Journal: MMWR Morb Mortal Wkly Rep Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Systemic Inflammatory Response Syndrome Type of study: Observational study / Prognostic study Topics: Long Covid / Variants Limits: Adolescent / Child / Child, preschool / Female / Humans / Male Country/Region as subject: North America Language: English Journal: MMWR Morb Mortal Wkly Rep Year: 2020 Document Type: Article