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Horses for courses? Assessing the potential value of a surrogate, point-of-care test for SARS-CoV-2 epidemic control.
Ismail, Sharif A; Huntley, Catherine; Post, Nathan; Rigby, Samuel; Shrotri, Madhumita; Williams, Sarah V; Peacock, Sharon J.
  • Ismail SA; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
  • Huntley C; Department of Primary Care and Public Health, Imperial College London, London, UK.
  • Post N; Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
  • Rigby S; Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
  • Shrotri M; Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
  • Williams SV; Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
  • Peacock SJ; Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, UK.
Influenza Other Respir Viruses ; 15(1): 3-6, 2021 01.
Article in English | MEDLINE | ID: covidwho-695884
ABSTRACT
Point-of-care tests (POCTs) offer considerable potential for improving clinical and public health management of COVID-19 by providing timely information to guide decision-making, but data on real-world performance are in short supply. Besides SARS-CoV-2-specific tests, there is growing interest in the role of surrogate (non-specific) tests such as FebriDx, a biochemical POCT which can be used to distinguish viral from bacterial infection in patients with influenza-like illnesses. This short report assesses what is currently known about FebriDx performance across settings and populations by comparison with some of the more intensively evaluated SARS-CoV-2-specific POCTs. While FebriDx shows some potential in supporting triage for early-stage infection in acute care settings, this is dependent on SARS-CoV-2 being the most likely cause for influenza-like illnesses, with reduction in discriminatory power when COVID-19 case numbers are low, and when co-circulating viral respiratory infections become more prevalent during the autumn and winter. Too little is currently known about its performance in primary care and the community to support use in these contexts, and further evaluation is needed. Reliable SARS CoV2-specific POCTs-when they become available-are likely to rapidly overtake surrogates as the preferred option given the greater specificity they provide.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Point-of-Care Testing / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Irv.12796

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Point-of-Care Testing / COVID-19 Testing / SARS-CoV-2 / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Journal: Influenza Other Respir Viruses Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Irv.12796