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A Novel Hypothesis for Original Antigenic Sin in the Severe Disease of SARS-CoV-2 Infection.
Kohler, Heinz; Nara, Peter.
  • Kohler H; Department of Microbiology and Immunology, University of Kentucky Emeritus, Lexington, Kentucky, USA.
  • Nara P; Keytstone Bio, Inc., St. Louis, Missouri, USA.
Monoclon Antib Immunodiagn Immunother ; 39(4): 107-111, 2020 Aug.
Article in English | MEDLINE | ID: covidwho-696013
ABSTRACT
In this hypothesis, we address the biological/immunological pathway leading to severe disease or death after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The underlying immune response is described with "original antigenic sin" (OAS) whereby previous infections influence the response to future virus encounters. We cite evidence for OAS-induced immunopathology in HIV-1 disease. We hypothesize that similar immune abnormalities can occur after infection with SARS-CoV-2. This hypothesis is supported by recent analysis of the antibodies in infected patients demonstrating serological and B cell abnormalities. The concept of symmetrical clonal regulation developed earlier for the immune network illustrates the pathway suggested by our hypothesis and may be helpful to develop strategies avoiding severe coronavirus disease 2019.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / B-Lymphocytes / Coronavirus Infections / Immune Evasion / Betacoronavirus / Antibodies, Viral Type of study: Randomized controlled trials Limits: Humans Language: English Journal: Monoclon Antib Immunodiagn Immunother Year: 2020 Document Type: Article Affiliation country: Mab.2020.0029

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / B-Lymphocytes / Coronavirus Infections / Immune Evasion / Betacoronavirus / Antibodies, Viral Type of study: Randomized controlled trials Limits: Humans Language: English Journal: Monoclon Antib Immunodiagn Immunother Year: 2020 Document Type: Article Affiliation country: Mab.2020.0029