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Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells: A case report.
Liang, Bing; Chen, Junhui; Li, Tao; Wu, Haiying; Yang, Wenjie; Li, Yanjiao; Li, Jianchun; Yu, Congtao; Nie, Fangang; Ma, Zhaoxia; Yang, Mingxi; Xiao, Mingying; Nie, Panrong; Gao, Yanfeng; Qian, Chuanyun; Hu, Min.
  • Liang B; Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.
  • Chen J; Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen.
  • Li T; Yunnan Yasheng Medical Technology Co., Ltd.
  • Wu H; Emergency Department of the First Affiliated Hospital of Kunming Medical University, EICU/MICU.
  • Yang W; Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.
  • Li Y; Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University.
  • Li J; Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.
  • Yu C; Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen.
  • Nie F; Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.
  • Ma Z; Yunnan Key Laboratory for Basic Research on Bone and Joint Diseases & Yunnan Stem Cell Translational Research Center, Kunming University.
  • Yang M; Yunnan Jici Institute for Regenerative Medicine Co., Ltd., Kunming.
  • Xiao M; Department of Critical Care Medicine, Baoshan People's Hospital, Baoshan.
  • Nie P; Department of Infectious Diseases.
  • Gao Y; Department of Neonatology, Baoshan People's Hospital, Baoshan.
  • Qian C; Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen.
  • Hu M; School of Life Sciences, Zhengzhou University, Zhengzhou, China.
Medicine (Baltimore) ; 99(31): e21429, 2020 Jul 31.
Article in English | MEDLINE | ID: covidwho-696106
Semantic information from SemMedBD (by NLM)
1. Human mesenchymal stem cell TREATS COVID-19
Subject
Human mesenchymal stem cell
Predicate
TREATS
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Human mesenchymal stem cell TREATS Patients
Subject
Human mesenchymal stem cell
Predicate
TREATS
Object
Patients
4. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
5. Human mesenchymal stem cell AFFECTS Immune response
Subject
Human mesenchymal stem cell
Predicate
AFFECTS
Object
Immune response
6. Human mesenchymal stem cell TREATS Critical Illness
Subject
Human mesenchymal stem cell
Predicate
TREATS
Object
Critical Illness
7. Fever PROCESS_OF Woman
Subject
Fever
Predicate
PROCESS_OF
Object
Woman
8. 2019 novel coronavirus INTERACTS_WITH Pneumonia
Subject
2019 novel coronavirus
Predicate
INTERACTS_WITH
Object
Pneumonia
9. Human mesenchymal stem cell TREATS COVID-19
Subject
Human mesenchymal stem cell
Predicate
TREATS
Object
COVID-19
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Human mesenchymal stem cell TREATS Patients
Subject
Human mesenchymal stem cell
Predicate
TREATS
Object
Patients
12. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
13. Human mesenchymal stem cell AFFECTS Immune response
Subject
Human mesenchymal stem cell
Predicate
AFFECTS
Object
Immune response
14. Human mesenchymal stem cell TREATS Critical Illness
Subject
Human mesenchymal stem cell
Predicate
TREATS
Object
Critical Illness
15. Fever PROCESS_OF Woman
Subject
Fever
Predicate
PROCESS_OF
Object
Woman
16. 2019 novel coronavirus INTERACTS_WITH Pneumonia
Subject
2019 novel coronavirus
Predicate
INTERACTS_WITH
Object
Pneumonia
ABSTRACT
RATIONALE The COVID-19 cases increased very fast in January and February 2020. The mortality among critically ill patients, especially the elder ones, is relatively high. Considering many patients died of severe inflammation response, it is urgent to develop effective therapeutic strategies for these patients. The human umbilical cord mesenchymal stem cells (hUCMSCs) have shown good capabilities to modulate the immune response and repair the injured tissue. Therefore, investigating the potential of hUCMSCs to the treatment of COVID-19 critically ill patients is necessary. PATIENT CONCERNS A 65-year-old woman felt fatigued and had a fever with body temperature of 38.2C, coughed up white foaming sputum. After 1 day, she had chest tightness with SPO2 of 81%, and blood pressure of 160/91 mm Hg. DIAGNOSE According to the guideline for the diagnosis and treatment of 2019 novel coronavirus infected pneumonia (Trial 4th Edition), COVID-19 was diagnosed, based on the real-time RT-PCR test of SARS-CoV-2.

INTERVENTIONS:

After regular treatment for 12 days, the inflammation symptom of the patient was still very severe and the potential side effects of corticosteroid were observed. Then, allogenic hUCMSCs were given 3 times (5 × 10 cells each time) with a 3-day interval, together with thymosin α1 and antibiotics daily injection.

OUTCOMES:

After these treatments, most of the laboratory indexes and CT images showed remission of the inflammation symptom. The patient was subsequently transferred out of ICU, and the throat swabs test reported negative 4 days later. LESSONS These results indicated the clinical outcome and good tolerance of allogenic hUCMSCs transfer.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / Coronavirus Infections / Cord Blood Stem Cell Transplantation / Mesenchymal Stem Cell Transplantation / Betacoronavirus Subject: Pneumonia, Viral / Coronavirus Infections / Cord Blood Stem Cell Transplantation / Mesenchymal Stem Cell Transplantation / Betacoronavirus Type of study: Case report Language: English Journal: Medicine (Baltimore) Clinical aspect: Therapy Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Document Type: Article Main subject: Pneumonia, Viral / Coronavirus Infections / Cord Blood Stem Cell Transplantation / Mesenchymal Stem Cell Transplantation / Betacoronavirus Subject: Pneumonia, Viral / Coronavirus Infections / Cord Blood Stem Cell Transplantation / Mesenchymal Stem Cell Transplantation / Betacoronavirus Type of study: Case report Language: English Journal: Medicine (Baltimore) Clinical aspect: Therapy Year: 2020
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