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Bacterial co-infections with SARS-CoV-2.
Mirzaei, Rasoul; Goodarzi, Pedram; Asadi, Muhammad; Soltani, Ayda; Aljanabi, Hussain Ali Abraham; Jeda, Ali Salimi; Dashtbin, Shirin; Jalalifar, Saba; Mohammadzadeh, Rokhsareh; Teimoori, Ali; Tari, Kamran; Salari, Mehdi; Ghiasvand, Sima; Kazemi, Sima; Yousefimashouf, Rasoul; Keyvani, Hossein; Karampoor, Sajad.
  • Mirzaei R; Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Goodarzi P; Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Asadi M; Faculty of Pharmacy, Iran University of Medical Sciences, Tehran, Iran.
  • Soltani A; Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Aljanabi HAA; School of Basic Sciences, Ale-Taha Institute of Higher Education, Tehran, Iran.
  • Jeda AS; Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Dashtbin S; Alnahrain University College of Medicine, Iraq.
  • Jalalifar S; Department of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Mohammadzadeh R; Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Teimoori A; Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Tari K; Department of Microbiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
  • Salari M; Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Ghiasvand S; Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Kazemi S; Department of Environmental Health Engineering, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Yousefimashouf R; Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Keyvani H; Department of Environmental Health Engineering, Hamadan University of Medical Sciences, Hamadan, Iran.
  • Karampoor S; Department of Microbiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
IUBMB Life ; 72(10): 2097-2111, 2020 10.
Article in English | MEDLINE | ID: covidwho-696287
ABSTRACT
The pandemic coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has affected millions of people worldwide. To date, there are no proven effective therapies for this virus. Efforts made to develop antiviral strategies for the treatment of COVID-19 are underway. Respiratory viral infections, such as influenza, predispose patients to co-infections and these lead to increased disease severity and mortality. Numerous types of antibiotics such as azithromycin have been employed for the prevention and treatment of bacterial co-infection and secondary bacterial infections in patients with a viral respiratory infection (e.g., SARS-CoV-2). Although antibiotics do not directly affect SARS-CoV-2, viral respiratory infections often result in bacterial pneumonia. It is possible that some patients die from bacterial co-infection rather than virus itself. To date, a considerable number of bacterial strains have been resistant to various antibiotics such as azithromycin, and the overuse could render those or other antibiotics even less effective. Therefore, bacterial co-infection and secondary bacterial infection are considered critical risk factors for the severity and mortality rates of COVID-19. Also, the antibiotic-resistant as a result of overusing must be considered. In this review, we will summarize the bacterial co-infection and secondary bacterial infection in some featured respiratory viral infections, especially COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Bacterial Infections / Pneumonia, Bacterial / Pandemics / COVID-19 / Anti-Bacterial Agents Type of study: Observational study / Prognostic study Language: English Journal: IUBMB Life Journal subject: Molecular Biology / Biochemistry Year: 2020 Document Type: Article Affiliation country: Iub.2356

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Bacterial Infections / Pneumonia, Bacterial / Pandemics / COVID-19 / Anti-Bacterial Agents Type of study: Observational study / Prognostic study Language: English Journal: IUBMB Life Journal subject: Molecular Biology / Biochemistry Year: 2020 Document Type: Article Affiliation country: Iub.2356