Inhibitory effects of Vitamin D on inflammation and IL-6 release. A further support for COVID-19 management?
Eur Rev Med Pharmacol Sci
; 24(15): 8187-8193, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-696399
ABSTRACT
The ongoing worldwide pandemic of Coronavirus disease 2019 (COVID-19), raised the urgency to address knowledge gaps and to establish evidence for improving management and control of this viral infection. Throughout a keen analysis of the World Health Organization (WHO) most updated data, a gender-specific difference in the occurrence of infection was determined, which seems to correlate with patient's vitamin D status. Therefore, our purpose is to provide insights into the nutritional importance of vitamin D for its immunomodulatory effect, in order to help counteracting the COVID-19 pandemic. Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections. Therefore, in addition to the standard recommendations to prevent the infection, supplementation of vitamin D might be considered an approach to help counteracting this global epidemic.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Pregnancy Proteins
/
Vitamin D
/
Vitamin D Deficiency
/
Vitamins
/
Interleukin-6
/
Suppressor Factors, Immunologic
/
Coronavirus Infections
Type of study:
Experimental Studies
/
Observational study
Limits:
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
Eur Rev Med Pharmacol Sci
Journal subject:
Pharmacology
/
Toxicology
Year:
2020
Document Type:
Article
Affiliation country:
Eurrev_202008_22507
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