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Inhibitory effects of Vitamin D on inflammation and IL-6 release. A further support for COVID-19 management?
Orrù, B; Szekeres-Bartho, J; Bizzarri, M; Spiga, A M; Unfer, V.
  • Orrù B; R&D Department, Lo.Li. Pharma S.r.l., Rome, Italy. vunfer@gmail.com.
Eur Rev Med Pharmacol Sci ; 24(15): 8187-8193, 2020 08.
Article in English | MEDLINE | ID: covidwho-696399
Semantic information from SemMedBD (by NLM)
1. ergocalciferol DISRUPTS Inflammation
Subject
ergocalciferol
Predicate
DISRUPTS
Object
Inflammation
2. COVID-19 AFFECTS Virus Diseases
Subject
COVID-19
Predicate
AFFECTS
Object
Virus Diseases
3. ergocalciferol AFFECTS Immunoregulation
Subject
ergocalciferol
Predicate
AFFECTS
Object
Immunoregulation
4. ergocalciferol DISRUPTS COVID-19
Subject
ergocalciferol
Predicate
DISRUPTS
Object
COVID-19
5. blocking factor AFFECTS Immune response
Subject
blocking factor
Predicate
AFFECTS
Object
Immune response
6. ergocalciferol INTERACTS_WITH interleukin-6
Subject
ergocalciferol
Predicate
INTERACTS_WITH
Object
interleukin-6
7. ergocalciferol AUGMENTS Infection
Subject
ergocalciferol
Predicate
AUGMENTS
Object
Infection
8. ergocalciferol DISRUPTS Inflammation
Subject
ergocalciferol
Predicate
DISRUPTS
Object
Inflammation
9. COVID-19 AFFECTS Virus Diseases
Subject
COVID-19
Predicate
AFFECTS
Object
Virus Diseases
10. ergocalciferol AFFECTS Immunoregulation
Subject
ergocalciferol
Predicate
AFFECTS
Object
Immunoregulation
11. ergocalciferol DISRUPTS COVID-19
Subject
ergocalciferol
Predicate
DISRUPTS
Object
COVID-19
12. blocking factor AFFECTS Immune response
Subject
blocking factor
Predicate
AFFECTS
Object
Immune response
13. ergocalciferol INTERACTS_WITH interleukin-6
Subject
ergocalciferol
Predicate
INTERACTS_WITH
Object
interleukin-6
14. ergocalciferol AUGMENTS Infection
Subject
ergocalciferol
Predicate
AUGMENTS
Object
Infection
ABSTRACT
The ongoing worldwide pandemic of Coronavirus disease 2019 (COVID-19), raised the urgency to address knowledge gaps and to establish evidence for improving management and control of this viral infection. Throughout a keen analysis of the World Health Organization (WHO) most updated data, a gender-specific difference in the occurrence of infection was determined, which seems to correlate with patient's vitamin D status. Therefore, our purpose is to provide insights into the nutritional importance of vitamin D for its immunomodulatory effect, in order to help counteracting the COVID-19 pandemic. Novel interesting findings suggest that vitamin D, by inducing progesterone-induced blocking factor (PIBF), might regulate the immune response and also modulate cytokine IL-6, which appears to be increased in COVID-19 infections. Therefore, in addition to the standard recommendations to prevent the infection, supplementation of vitamin D might be considered an approach to help counteracting this global epidemic.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Proteins / Vitamin D / Vitamin D Deficiency / Vitamins / Interleukin-6 / Suppressor Factors, Immunologic / Coronavirus Infections Limits: Humans Country/Region as subject: Europa Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2020 Document Type: Article Affiliation country: Eurrev_202008_22507

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Proteins / Vitamin D / Vitamin D Deficiency / Vitamins / Interleukin-6 / Suppressor Factors, Immunologic / Coronavirus Infections Limits: Humans Country/Region as subject: Europa Language: English Journal: Eur Rev Med Pharmacol Sci Journal subject: Pharmacology / Toxicology Year: 2020 Document Type: Article Affiliation country: Eurrev_202008_22507