Your browser doesn't support javascript.
Association of history of cerebrovascular disease with severity of COVID-19.
Siepmann, Timo; Sedghi, Annahita; Barlinn, Jessica; de With, Katja; Mirow, Lutz; Wolz, Martin; Gruenewald, Thomas; Helbig, Sina; Schroettner, Percy; Winzer, Simon; von Bonin, Simone; Moustafa, Haidar; Pallesen, Lars-Peder; Rosengarten, Bernhard; Schubert, Joerg; Gueldner, Andreas; Spieth, Peter; Koch, Thea; Bornstein, Stefan; Reichmann, Heinz; Puetz, Volker; Barlinn, Kristian.
  • Siepmann T; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany. timo.siepmann@ukdd.de.
  • Sedghi A; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
  • Barlinn J; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
  • de With K; Division of Infectious Diseases, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Mirow L; Department of General and Visceral Surgery, Klinikum Chemnitz gGmbH, Chemnitz, Germany.
  • Wolz M; Department of Neurology, Elblandklinikum Meißen, Meißen, Germany.
  • Gruenewald T; Department of Infectious Diseases/Tropical Medicine, Klinikum Chemnitz gGmbH, Chemnitz, Germany.
  • Helbig S; Division of Infectious Diseases, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Schroettner P; Department of Virology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Winzer S; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
  • von Bonin S; Department of Virology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Moustafa H; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
  • Pallesen LP; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
  • Rosengarten B; Department of Neurology, Klinikum Chemnitz gGmbH, Chemnitz, Germany.
  • Schubert J; Department of Hematology and Oncology, Elblandklinikum Riesa, Riesa, Germany.
  • Gueldner A; Department of Anesthesiology and Intensive Care, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Spieth P; Department of Anesthesiology and Intensive Care, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Koch T; Department of Anesthesiology and Intensive Care, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Bornstein S; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
  • Reichmann H; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
  • Puetz V; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
  • Barlinn K; Department of Neurology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
J Neurol ; 268(3): 773-784, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-696700
ABSTRACT

OBJECTIVE:

To determine whether a history of cerebrovascular disease (CVD) increases risk of severe coronavirus disease 2019 (COVID-19).

METHODS:

In a retrospective multicenter study, we retrieved individual data from in-patients treated March 1 to April 15, 2020 from COVID-19 registries of three hospitals in Saxony, Germany. We also performed a systematic review and meta-analysis following PRISMA recommendations using PubMed, EMBASE, Cochrane Library databases and bibliographies of identified papers (last search on April 11, 2020) and pooled data with those deriving from our multicenter study. Of 3762 records identified, 11 eligible observational studies of laboratory-confirmed COVID-19 patients were included in quantitative data synthesis. Risk ratios (RR) of severe COVID-19 according to history of CVD were pooled using DerSimonian and Laird random effects model. Between-study heterogeneity was assessed using Cochran's Q and I2-statistics. Severity of COVID-19 according to definitions applied in included studies was the main outcome. Sensitivity analyses were conducted for clusters of studies with equal definitions of severity.

RESULTS:

Pooled analysis included data from 1906 laboratory-confirmed COVID-19 patients (43.9% females, median age ranging from 39 to 76 years). Patients with previous CVD had higher risk of severe COVID-19 than those without [RR 2.07, 95% confidence interval (CI) 1.52-2.81; p < 0.0001]. This association was also observed in clusters of studies that defined severe manifestation of the disease by clinical parameters (RR 1.44, 95% CI 1.22-1.71; p < 0.0001), necessity of intensive care (RR 2.79, 95% CI 1.83-4.24; p < 0.0001) and in-hospital death (RR 2.18, 95% CI 1.75-2.7; p < 0.0001).

CONCLUSION:

A history of CVD might constitute an important risk factor of unfavorable clinical course of COVID-19  suggesting a need of tailored infection prevention and clinical management strategies for this population at risk.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrovascular Disorders / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Neurol Year: 2021 Document Type: Article Affiliation country: S00415-020-10121-0

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Cerebrovascular Disorders / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Neurol Year: 2021 Document Type: Article Affiliation country: S00415-020-10121-0