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Coronavirus Detection in the Clinical Microbiology Laboratory: Are We Ready for Identifying and Diagnosing a Novel Virus?
Uhteg, Katharine; Carroll, Karen C; Mostafa, Heba H.
  • Uhteg K; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Meyer B-121F, 600 North Wolfe Street, Baltimore, MD 21287-7093, USA.
  • Carroll KC; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Meyer B-121F, 600 North Wolfe Street, Baltimore, MD 21287-7093, USA.
  • Mostafa HH; Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Meyer B-121F, 600 North Wolfe Street, Baltimore, MD 21287-7093, USA. Electronic address: hmostaf2@jhmi.edu.
Clin Lab Med ; 40(4): 459-472, 2020 12.
Article in English | MEDLINE | ID: covidwho-696842
ABSTRACT
Endemic species of coronavirus (HCoV-OC43, HCoV-229E, HCoV-NL63, and HCoV-HKU1) are frequent causes of upper respiratory tract infections. Three highly pathogenic coronaviruses have been associated with outbreaks and epidemics and have challenged clinical microbiology laboratories to quickly develop assays for diagnosis. Their initial characterization was achieved by molecular methods. With the great advance in metagenomic whole-genome sequencing directly from clinical specimens, diagnosis of novel coronaviruses could be quickly implemented into the workflow of managing cases of pneumonia of unknown cause, which will markedly affect the time of the initial characterization and accelerate the initiation of outbreak control measures.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Communicable Disease Control / Disease Outbreaks / Microbiological Techniques / Coronavirus Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Lab Med Year: 2020 Document Type: Article Affiliation country: J.cll.2020.08.004

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Communicable Disease Control / Disease Outbreaks / Microbiological Techniques / Coronavirus Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Clin Lab Med Year: 2020 Document Type: Article Affiliation country: J.cll.2020.08.004