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Pandemic printing: a novel 3D-printed swab for detecting SARS-CoV-2.
Williams, Eloise; Bond, Katherine; Isles, Nicole; Chong, Brian; Johnson, Douglas; Druce, Julian; Hoang, Tuyet; Ballard, Susan A; Hall, Victoria; Muhi, Stephen; Buising, Kirsty L; Lim, Seok; Strugnell, Dick; Catton, Mike; Irving, Louis B; Howden, Benjamin P; Bert, Eric; Williamson, Deborah A.
  • Williams E; Royal Melbourne Hospital, Melbourne, VIC.
  • Bond K; Royal Melbourne Hospital, Melbourne, VIC.
  • Isles N; University of Melbourne, Melbourne, VIC.
  • Chong B; Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC.
  • Johnson D; Royal Melbourne Hospital, Melbourne, VIC.
  • Druce J; Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC.
  • Hoang T; Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC.
  • Ballard SA; Austin Health, Melbourne, VIC.
  • Hall V; Royal Melbourne Hospital, Melbourne, VIC.
  • Muhi S; Royal Melbourne Hospital, Melbourne, VIC.
  • Buising KL; Royal Melbourne Hospital, Melbourne, VIC.
  • Lim S; University of Melbourne, Melbourne, VIC.
  • Strugnell D; Royal Melbourne Hospital, Melbourne, VIC.
  • Catton M; University of Melbourne, Melbourne, VIC.
  • Irving LB; Victorian Infectious Diseases Reference Laboratory, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC.
  • Howden BP; Royal Melbourne Hospital, Melbourne, VIC.
  • Bert E; Public Health Laboratory, University of Melbourne, Melbourne, VIC.
  • Williamson DA; 3DMEDitech, Melbourne, VIC.
Med J Aust ; 213(6): 276-279, 2020 09.
Article in English | MEDLINE | ID: covidwho-696938
ABSTRACT

OBJECTIVES:

To design and evaluate 3D-printed nasal swabs for collection of samples for SARS-CoV-2 testing.

DESIGN:

An iterative design process was employed. Laboratory evaluation included in vitro assessment of mock nasopharyngeal samples spiked with two different concentrations of gamma-irradiated SARS-CoV-2. A prospective clinical study compared SARS-CoV-2 and human cellular material recovery by 3D-printed swabs and standard nasopharyngeal swabs. SETTING,

PARTICIPANTS:

Royal Melbourne Hospital, May 2020. Participants in the clinical evaluation were 50 hospital staff members attending a COVID-19 screening clinic and two inpatients with laboratory-confirmed COVID-19. INTERVENTION In the clinical evaluation, a flocked nasopharyngeal swab sample was collected with the Copan ESwab and a mid-nasal sample from the other nostril was collected with the 3D-printed swab.

RESULTS:

In the laboratory evaluation, qualitative agreement with regard to SARS-CoV-2 detection in mock samples collected with 3D-printed swabs and two standard swabs was complete. In the clinical evaluation, qualitative agreement with regard to RNase P detection (a surrogate measure of adequate collection of human cellular material) in samples collected from 50 hospital staff members with standard and 3D-printed swabs was complete. Qualitative agreement with regard to SARS-CoV-2 detection in three pairs of 3D-printed mid-nasal and standard swab samples from two inpatients with laboratory-confirmed SARS-CoV-2 was also complete.

CONCLUSIONS:

Using 3D-printed swabs to collect nasal samples for SARS-CoV-2 testing is feasible, acceptable to patients and health carers, and convenient.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Patient Acceptance of Health Care / Coronavirus Infections / Clinical Laboratory Techniques / Diagnostic Techniques, Respiratory System / Printing, Three-Dimensional Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Qualitative research Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Med J Aust Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Patient Acceptance of Health Care / Coronavirus Infections / Clinical Laboratory Techniques / Diagnostic Techniques, Respiratory System / Printing, Three-Dimensional Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Qualitative research Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Med J Aust Year: 2020 Document Type: Article