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The evidence of indirect transmission of SARS-CoV-2 reported in Guangzhou, China.
Xie, Chaojun; Zhao, Hongjun; Li, Kuibiao; Zhang, Zhoubin; Lu, Xiaoxiao; Peng, Huide; Wang, Dahu; Chen, Jin; Zhang, Xiao; Wu, Di; Gu, Yuzhou; Yuan, Jun; Zhang, Lin; Lu, Jiachun.
  • Xie C; The Institute for Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, PR China.
  • Zhao H; Guangzhou Center for Disease Control and Prevention, 1Qide Road, Guangzhou, 510440, PR China.
  • Li K; The Institute for Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, PR China.
  • Zhang Z; State Key Lab of Respiratory Disease, The First Affiliated Hospital, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, PR China.
  • Lu X; The Institute for Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, PR China.
  • Peng H; Guangzhou Center for Disease Control and Prevention, 1Qide Road, Guangzhou, 510440, PR China.
  • Wang D; The Institute for Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, PR China.
  • Chen J; Guangzhou Center for Disease Control and Prevention, 1Qide Road, Guangzhou, 510440, PR China.
  • Zhang X; Department of English and American Studies, Faculty of Languages and Literatures, Ludwig Maximilian University (LMU), Munich, Germany.
  • Wu D; Baiyun District Center for Disease Control and Prevention, Guangzhou, PR China.
  • Gu Y; The Institute for Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, PR China.
  • Yuan J; Guangzhou Center for Disease Control and Prevention, 1Qide Road, Guangzhou, 510440, PR China.
  • Zhang L; Baiyun District Center for Disease Control and Prevention, Guangzhou, PR China.
  • Lu J; The Institute for Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, PR China.
BMC Public Health ; 20(1): 1202, 2020 Aug 05.
Article in English | MEDLINE | ID: covidwho-696961
ABSTRACT

BACKGROUND:

More than 2 months have passed since the novel coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China. With the migration of people, the epidemic has rapidly spread within China and throughout the world. Due to the severity of the epidemic, undiscovered transmission of COVID-19 deserves further investigation. The aim of our study hypothesized possible modes of SARS-CoV-2 transmission and how the virus may have spread between two family clusters within a residential building in Guangzhou, China.

METHODS:

In a cross-sectional study, we monitored and traced confirmed patients and their close contacts from January 11 to February 5, 2020 in Guangzhou, China, including 2 family cluster cases and 61 residents within one residential building. The environmental samples of the building and the throat swabs from the patients and from their related individuals were collected for SARS-CoV-2 and tested with real-time reverse transcriptase polymerase chain reaction (RT-PCR). The relevant information was collected and reported using big data tools.

RESULTS:

There were two notable family cluster cases in Guangzhou, which included 3 confirmed patients (family No.1 patient A, B, C) and 2 confirmed patients (family No.2 patient D, E), respectively. None of patients had contact with other confirmed patients before the onset of symptoms, and only patient A and patient B made a short stop in Wuhan by train. Home environment inspection results showed that the door handle of family No.1 was positive of SARS-CoV-2. The close contacts of the 5 patients all tested negative of SARS-CoV-2 and in good health, and therefore were released after the official medical observation period of 14-days. Finally, according to the traceability investigation through applying big data analysis, we found an epidemiological association between family No.1 and family No.2, in which patient D (family No.2) was infected through touching an elevator button contaminated by snot with virus from patient A (family No.1) on the same day.

CONCLUSIONS:

Contaminants with virus from confirmed patients can pollute the environment of public places, and the virus can survive on the surface of objects for a short period of time. Therefore, in addition to the conventional droplet transmission, there is also indirect contact transmission such as snot-oral transmission that plays a crucial role in community spread of the virus.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Family / Coronavirus Infections / Betacoronavirus Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: BMC Public Health Journal subject: Public Health Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Family / Coronavirus Infections / Betacoronavirus Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: BMC Public Health Journal subject: Public Health Year: 2020 Document Type: Article