Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase.

Xu, Yechun; Jiang, Hualiang

Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase.

Xu, Yechun; Jiang, Hualiang.

Xu Y; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Jiang H; University of Chinese Academy of Sciences, Beijing, 100049, China.

Protein Cell ; 11(10): 699-702, 2020 10.

Article in English | MEDLINE | ID: covidwho-696966

Subject(s)

Betacoronavirus; Coronavirus Infections/drug therapy; Enzyme Inhibitors/therapeutic use; Oxidoreductases/antagonists & inhibitors; Pandemics; Pneumonia, Viral/drug therapy; Animals; COVID-19; Dihydroorotate Dehydrogenase; Drug Discovery; Drug Evaluation, Preclinical; Humans; Mice; Molecular Structure; Orthomyxoviridae Infections/drug therapy; Oseltamivir/therapeutic use; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines/biosynthesis; SARS-CoV-2; COVID-19 Drug Treatment

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Oxidoreductases / Pneumonia, Viral / Coronavirus Infections / Enzyme Inhibitors / Pandemics / Betacoronavirus Type of study: Prognostic study Topics: Traditional medicine Limits: Animals / Humans Language: English Journal: Protein Cell Journal subject: Biochemistry Year: 2020 Document Type: Article Affiliation country: S13238-020-00769-9

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