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Genomics approaches to synthesize plant-based biomolecules for therapeutic applications to combat SARS-CoV-2.
Sharma, Namisha; Muthamilarasan, Mehanathan; Prasad, Ashish; Prasad, Manoj.
  • Sharma N; National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India.
  • Muthamilarasan M; Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, Telangana, India.
  • Prasad A; National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India.
  • Prasad M; National Institute of Plant Genome Research, Aruna Asaf Ali Marg, New Delhi 110067, India. Electronic address: manoj_prasad@nipgr.ac.in.
Genomics ; 112(6): 4322-4331, 2020 11.
Article in English | MEDLINE | ID: covidwho-701714
ABSTRACT
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is devastative to the humankind for which neither vaccines nor precise therapeutic molecules for treatment are identified. The search for new drugs and repurposing of existing drugs are being performed; however, at the same time, research on plants to identify novel therapeutic compounds or testing the existing ones is progressing at a slower phase. In this context, genomics and biotechnology offer various tools and strategies to manipulate plants for producing those complex biopharmaceutical products. This review enumerates the scope for research on plant-based molecules for their potential application in treating SARS-CoV-2 infection. Strategies to edit gene and genome, overexpression and silencing approaches, and molecular breeding for producing target biomolecules in the plant system are discussed in detail. Altogether, the present review provides a roadmap for expediting research on using plants as a novel source of active biomolecules having therapeutic applications.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Plants / Genomics Topics: Vaccines Limits: Humans Language: English Journal: Genomics Journal subject: Genetics Year: 2020 Document Type: Article Affiliation country: J.ygeno.2020.07.033

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Plants / Genomics Topics: Vaccines Limits: Humans Language: English Journal: Genomics Journal subject: Genetics Year: 2020 Document Type: Article Affiliation country: J.ygeno.2020.07.033