Prevalence and characterization of asthma in hospitalized and nonhospitalized patients with COVID-19.
J Allergy Clin Immunol
; 146(2): 307-314.e4, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-701780
ABSTRACT
BACKGROUND:
The Centers for Disease Control and Prevention advises that patients with moderate to severe asthma belong to a high-risk group that is susceptible to severe coronavirus disease 2019 (COVID-19). However, the association between asthma and COVID-19 has not been well-established.OBJECTIVE:
The primary objective was to determine the prevalence of asthma among patients with COVID-19 in a major US health system. We assessed the clinical characteristics and comorbidities in asthmatic and nonasthmatic patients with COVID-19. We also determined the risk of hospitalization associated with asthma and/or inhaled corticosteroid use.METHODS:
Medical records of patients with COVID-19 were searched by a computer algorithm (March 1 to April 15, 2020), and chart review was used to validate the diagnosis of asthma and medications prescribed for asthma. All patients had PCR-confirmed COVID-19. Demographic and clinical features were characterized. Regression models were used to assess the associations between asthma and corticosteroid use and the risk of COVID-19-related hospitalization.RESULTS:
Of 1526 patients identified with COVID-19, 220 (14%) were classified as having asthma. Asthma was not associated with an increased risk of hospitalization (relative risk, 0.96; 95% CI, 0.77-1.19) after adjusting for age, sex, and comorbidities. The ongoing use of inhaled corticosteroids did not increase the risk of hospitalization in a similar adjusted model (relative risk, 1.39; 95% CI, 0.90-2.15).CONCLUSIONS:
Despite a substantial prevalence of asthma in our COVID-19 cohort, asthma was not associated with an increased risk of hospitalization. Similarly, the use of inhaled corticosteroids with or without systemic corticosteroids was not associated with COVID-19-related hospitalization.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Asthma
/
Coronary Artery Disease
/
Coronavirus Infections
/
Diabetes Mellitus
/
Betacoronavirus
/
Hypertension
/
Obesity
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
Country/Region as subject:
North America
Language:
English
Journal:
J Allergy Clin Immunol
Year:
2020
Document Type:
Article
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