Critical COVID-19 disease, homeostasis, and the "surprise" of effective glucocorticoid therapy.

Chrousos, George P; Meduri, G Umberto

Chrousos, George P; Meduri, G Umberto.

Chrousos GP; National and Kapodistrian University of Athens, Athens, Greece. Electronic address: chrousge@med.uoa.gr.
Meduri GU; University of Tennessee, Health Sciences Center, Memphis, TN, United States. Electronic address: gmeduri@uthsc.edu.

Clin Immunol ; 219: 108550, 2020 10.

Article in English | MEDLINE | ID: covidwho-702942

Subject(s)

Anti-Inflammatory Agents/therapeutic use; Coronavirus Infections/drug therapy; Cytokine Release Syndrome/drug therapy; Glucocorticoids/therapeutic use; Homeostasis/drug effects; Pneumonia, Viral/drug therapy; Betacoronavirus/drug effects; Betacoronavirus/immunology; Betacoronavirus/pathogenicity; Biomarkers/blood; COVID-19; Coronavirus Infections/immunology; Coronavirus Infections/metabolism; Coronavirus Infections/virology; Cytokine Release Syndrome/immunology; Cytokine Release Syndrome/metabolism; Cytokine Release Syndrome/virology; Cytokines/antagonists & inhibitors; Cytokines/genetics; Cytokines/immunology; Drug Administration Schedule; Gene Expression Regulation; Homeostasis/immunology; Humans; Hydrocortisone/blood; Immunity, Innate/drug effects; Inflammation/prevention & control; NF-kappa B/genetics; NF-kappa B/immunology; Pandemics; Pneumonia, Viral/immunology; Pneumonia, Viral/metabolism; Pneumonia, Viral/virology; SARS-CoV-2; Stress, Physiological; Treatment Outcome; Vitamins/blood

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Cytokine Release Syndrome / Glucocorticoids / Homeostasis / Anti-Inflammatory Agents Type of study: Experimental Studies / Prognostic study Language: English Journal: Clin Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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