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Clinical characteristics and risk factors for severe COVID-19 in hospitalized kidney transplant recipients: A multicentric cohort study.
Favà, Alexandre; Cucchiari, David; Montero, Nuria; Toapanta, Nestor; Centellas, Francisco J; Vila-Santandreu, Anna; Coloma, Ana; Meneghini, Maria; Manonelles, Anna; Sellarés, Joana; Torres, Irina; Gelpi, Rosana; Lorenzo, Inmaculada; Ventura-Aguiar, Pedro; Cofan, Frederic; Torregrosa, Jose V; Perelló, Manel; Facundo, Carme; Seron, Daniel; Oppenheimer, Federico; Bestard, Oriol; Cruzado, Josep M; Moreso, Francesc; Melilli, Edoardo.
  • Favà A; Nephrology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
  • Cucchiari D; Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Barcelona, Spain.
  • Montero N; Nephrology Department, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Toapanta N; Nephrology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
  • Centellas FJ; Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Barcelona, Spain.
  • Vila-Santandreu A; Nephrology Department, Hospital de Vall d' Hebron, Barcelona, Spain.
  • Coloma A; Nephrology Department, Complejo Hospitalario Universitario de Albacete, Albacete, Spain.
  • Meneghini M; Nephrology Department, Fundació Puigvert, Barcelona, Spain.
  • Manonelles A; Nephrology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
  • Sellarés J; Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Barcelona, Spain.
  • Torres I; Nephrology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
  • Gelpi R; Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Barcelona, Spain.
  • Lorenzo I; Nephrology Department, Hospital Universitari de Bellvitge, Barcelona, Spain.
  • Ventura-Aguiar P; Biomedical Research Institute (IDIBELL), Hospital Duran i Reynals, Barcelona, Spain.
  • Cofan F; Nephrology Department, Hospital de Vall d' Hebron, Barcelona, Spain.
  • Torregrosa JV; Nephrology Department, Hospital de Vall d' Hebron, Barcelona, Spain.
  • Perelló M; Nephrology Department, Fundació Puigvert, Barcelona, Spain.
  • Facundo C; Nephrology Department, Hospital de Vall d' Hebron, Barcelona, Spain.
  • Seron D; Nephrology Department, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Oppenheimer F; Nephrology Department, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Bestard O; Nephrology Department, Hospital Clínic de Barcelona, Barcelona, Spain.
  • Cruzado JM; Nephrology Department, Hospital de Vall d' Hebron, Barcelona, Spain.
  • Moreso F; Nephrology Department, Fundació Puigvert, Barcelona, Spain.
  • Melilli E; Nephrology Department, Hospital de Vall d' Hebron, Barcelona, Spain.
Am J Transplant ; 20(11): 3030-3041, 2020 11.
Article in English | MEDLINE | ID: covidwho-703595
ABSTRACT
Kidney transplant recipients might be at higher risk for severe coronavirus disease 2019 (COVID-19). However, risk factors for relevant outcomes remain uncertain in this population. This is a multicentric kidney transplant cohort including 104 hospitalized patients between March 4 and April 17, 2020. Risk factors for death and acute respiratory distress syndrome (ARDS) were investigated, and clinical and laboratory data were analyzed. The mean age was 60 years. Forty-seven patients (54.8%) developed ARDS. Obesity was associated to ARDS development (OR 2.63; P = .04). Significant age differences were not found among patients developing and not developing ARDS (61.3 vs 57.8 years, P = .16). Seventy-six (73%) patients were discharged, and 28 (27%) died. Death was more common among the elderly (55 and 70.8 years, P < .001) and those with preexisting pulmonary disease (OR 2.89, P = .009). At admission, higher baseline lactate dehydrogenase (257 vs 358 IU/mL, P = .001) or ARDS conferred higher risk of death (HR 2.09, P = .044). In our cohort, ARDS was equally present among young and old kidney recipients. However, the elderly might be at higher risk of death, along with those showing higher baseline LDH at admission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / Risk Assessment / Renal Insufficiency / Transplant Recipients / SARS-CoV-2 / COVID-19 / Inpatients Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: Ajt.16246

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Kidney Transplantation / Risk Assessment / Renal Insufficiency / Transplant Recipients / SARS-CoV-2 / COVID-19 / Inpatients Type of study: Cohort study / Observational study / Prognostic study Limits: Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Am J Transplant Journal subject: Transplantation Year: 2020 Document Type: Article Affiliation country: Ajt.16246