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Approaches and Challenges in SARS-CoV-2 Vaccine Development.
Dagotto, Gabriel; Yu, Jingyou; Barouch, Dan H.
  • Dagotto G; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Yu J; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA.
  • Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA; Massachusetts Consortium on Pathogen Readiness, Boston, MA 02215, USA. Electronic address: dbarouch@bidmc.harvard.edu.
Cell Host Microbe ; 28(3): 364-370, 2020 09 09.
Article in English | MEDLINE | ID: covidwho-703970
ABSTRACT
The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2020 Document Type: Article Affiliation country: J.chom.2020.08.002

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Viral Vaccines / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Experimental Studies / Observational study / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Cell Host Microbe Journal subject: Microbiology Year: 2020 Document Type: Article Affiliation country: J.chom.2020.08.002