Modeling Potential Autophagy Pathways in COVID-19 and Sarcoidosis.

Calender, Alain; Israel-Biet, Dominique; Valeyre, Dominique; Pacheco, Yves

Calender, Alain; Israel-Biet, Dominique; Valeyre, Dominique; Pacheco, Yves.

Calender A; Department of Genetics, University Hospital, University Claude Bernard Lyon 1, Lyon, France. Electronic address: alain.calender@chu-lyon.fr.
Israel-Biet D; Department of Pulmonology AP-HP, Georges Pompidou European Hospital, Paris, France.
Valeyre D; Department of Pulmonology, Avicenne Hospital, Bobigny, France; Saint Joseph Hospital, APHP, Paris, France; University Sorbonne Paris Nord, INSERM UMR 1272, Villetaneuse, France.
Pacheco Y; Department of Genetics, University Hospital, University Claude Bernard Lyon 1, Lyon, France.

Trends Immunol ; 41(10): 856-859, 2020 10.

Article in English | MEDLINE | ID: covidwho-703987

ABSTRACT

ABSTRACT

Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and mainly affects the lungs. Sarcoidosis is an autoinflammatory disease characterized by the diffusion of granulomas in the lungs and other organs. Here, we discuss how the two diseases might involve some common mechanistic cellular pathways around the regulation of autophagy.

Subject(s)

Autophagy/drug effects; Betacoronavirus/pathogenicity; Coronavirus Infections/drug therapy; Pneumonia, Viral/drug therapy; Pulmonary Edema/drug therapy; Sarcoidosis/drug therapy; Severe Acute Respiratory Syndrome/drug therapy; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Autophagy/genetics; Azithromycin/therapeutic use; Betacoronavirus/growth & development; COVID-19; Chloroquine/therapeutic use; Coronavirus Infections/epidemiology; Coronavirus Infections/genetics; Coronavirus Infections/virology; Host-Pathogen Interactions/drug effects; Humans; Isoniazid/therapeutic use; Lung/drug effects; Lung/pathology; Lung/virology; Pandemics; Pneumonia, Viral/epidemiology; Pneumonia, Viral/genetics; Pneumonia, Viral/virology; Pulmonary Edema/epidemiology; Pulmonary Edema/genetics; Pulmonary Edema/virology; Rifampin/therapeutic use; SARS-CoV-2; Sarcoidosis/epidemiology; Sarcoidosis/genetics; Sarcoidosis/virology; Severe Acute Respiratory Syndrome/epidemiology; Severe Acute Respiratory Syndrome/genetics; Severe Acute Respiratory Syndrome/virology; Severity of Illness Index

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pulmonary Edema / Sarcoidosis / Autophagy / Coronavirus Infections / Severe Acute Respiratory Syndrome / Betacoronavirus Type of study: Observational study / Prognostic study Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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