Potential mechanisms of Chinese Herbal Medicine that implicated in the treatment of COVID-19 related renal injury.
Saudi Pharm J
; 28(9): 1138-1148, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-703998
ABSTRACT
Clinical studies have shown that renal injury in Corona Virus Disease 2019 (COVID-19) patients has been a real concern, which is associated with high mortality and an inflammation/apoptosis-related causality. Effective target therapy for renal injury has yet been developed. Besides, potential anti-COVID-19 medicines have also been reported to cause adverse side effects to kidney. Chinese Herbal Medicine (CHM), however, has rich experience in treating renal injury and has successfully applied in China in the battle of COVID-19. Nevertheless, the molecular mechanisms of CHM treatment are still unclear. In this study, we searched prescriptions in the treatment of renal injury extensively and the potential mechanisms to treat COVID-19 related renal injury were investigated. The association rules analysis showed that the core herbs includes Huang Qi, Fu Ling, Bai Zhu, Di Huang, Shan Yao. TCM herbs regulate core pathways, such as AGE-RAGE, PI3K-AKT, TNF and apoptosis pathway, etc. The ingredients (quercetin, formononetin, kaempferol, etc.,) from core herbs could modulate targets (PTGS2 (COX2), PTGS1 (COX1), IL6, CASP3, NOS2, and TNF, etc.), and thereby prevent the pharmacological and non-pharmacological renal injury comparable to that from COVID-19 infection. This study provides therapeutic potentials of CHM to combat COVID-19 related renal injury to reduce complications and mortality.
AGE, Advanced Glycation End products; AKT, Protein Kinase B; Association rules; CHM, Chinese Herbal medicine; CNKI, China National Knowledge Infrastructure; COVID-19; COVID-19, Corona Virus Disease 2019; CRRT, continuous renal replacement therapy; Chinese Herbal Medicine; IL6, interleukin 6; KEGG, Kyoto Encyclopedia of Genes and Genomes; MERS, Middle East respiratory syndrome; NCBI, National Coalition Building Institute; NHC, National Health Commission; NOS2, Nitric Oxide synthase; Network pharmacology; PI3K, Phosphatidylinositol 3-kinase; PPI, proteinprotein interaction; PTGS1, Prostaglandin G/H synthase 1; PTGS2, Prostaglandin G/H synthase 2; RAGE, Receptor of Advanced Glycation End products; Renal/kidney injury; SARS, severe acute respiratory syndrome; TCMSP, Traditional Chinese Medicine Systems Pharmacology; TNF, Tumor Necrosis Factor; Traditional Chinese Medicine
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Topics:
Traditional medicine
Language:
English
Journal:
Saudi Pharm J
Year:
2020
Document Type:
Article
Affiliation country:
J.jsps.2020.08.002
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