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Repurposing of SARS-CoV nucleocapsid protein specific nuclease resistant RNA aptamer for therapeutics against SARS-CoV-2.
Parashar, Nidarshana Chaturvedi; Poddar, Jit; Chakrabarti, Sasanka; Parashar, Gaurav.
  • Parashar NC; Department of Biotechnology, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.
  • Poddar J; Department of Biochemistry and Central Research Cell, MM Institute of Medical Sciences & Research, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.
  • Chakrabarti S; Department of Biochemistry and Central Research Cell, MM Institute of Medical Sciences & Research, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India.
  • Parashar G; Department of Biotechnology, Maharishi Markandeshwar (deemed to be) University, Mullana, Haryana, India. Electronic address: parashar_panchal@yahoo.co.in.
Infect Genet Evol ; 85: 104497, 2020 11.
Article in English | MEDLINE | ID: covidwho-704005
ABSTRACT
COVID-19 pandemic is rapidly advancing among human population. Development of new interventions including therapeutics and vaccines against SARS-CoV-2 will require time and validation before it could be made available for public use. Keeping in view of the emergent and evolving situation the motive is to repurpose and test the immediate efficacy of available drugs and therapeutics against COVID-19. Through this article we propose and discuss the possibility of repurposing the available nuclease resistant RNA aptamer against the nucleocapsid protein of SARS-CoV as a potential therapeutic agent for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Viral Structural Proteins / Aptamers, Nucleotide / SARS-CoV-2 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Infect Genet Evol Journal subject: Biology / Communicable Diseases / Genetics Year: 2020 Document Type: Article Affiliation country: J.meegid.2020.104497

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Viral Structural Proteins / Aptamers, Nucleotide / SARS-CoV-2 Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Infect Genet Evol Journal subject: Biology / Communicable Diseases / Genetics Year: 2020 Document Type: Article Affiliation country: J.meegid.2020.104497