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Host Polymorphisms May Impact SARS-CoV-2 Infectivity.
Brest, Patrick; Refae, Sadal; Mograbi, Baharia; Hofman, Paul; Milano, Gerard.
  • Brest P; Université Côte d'Azur, Centre Antoine Lacassagne, CNRS, Inserm, IRCAN, FHU-OncoAge, Nice, F-06189, France.
  • Refae S; Université Côte d'Azur, Centre Antoine Lacassagne, EA7497, Nice, F-06100 France; Ministry of National Guard - Health Affairs (NGHA), Al Madinah Kingdom of Saudi Arabia, Riyadh 11426, Saudi Arabia.
  • Mograbi B; Université Côte d'Azur, Centre Antoine Lacassagne, CNRS, Inserm, IRCAN, FHU-OncoAge, Nice, F-06189, France.
  • Hofman P; Université Côte d'Azur, Centre Antoine Lacassagne, CNRS, Inserm, IRCAN, FHU-OncoAge, Nice, F-06189, France; Université Côte d'Azur, CHU-Nice, Laboratory of Clinical and Experimental Pathology, FHU OncoAge, Hospital-Integrated Biobank (BB-0033-00025), Nice, F-06001, France.
  • Milano G; Université Côte d'Azur, Centre Antoine Lacassagne, EA7497, Nice, F-06100 France. Electronic address: gerard.milano@nice.unicancer.fr.
Trends Genet ; 36(11): 813-815, 2020 11.
Article in English | MEDLINE | ID: covidwho-704022
ABSTRACT
Based on a broad public database compilation, we support the hypothesis that germinal polymorphisms may regulate the expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) cellular target itself and proteases controlling the process of its shedding or, conversely, its internalization. Consequently, a genetic influence on individual susceptibility to coronavirus disease 2019 (COVID-19) infection is strongly suspected.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Polymorphism, Genetic / Serine Endopeptidases / Coronavirus Infections / Peptidyl-Dipeptidase A / ADAM17 Protein / Betacoronavirus Type of study: Experimental Studies Limits: Humans Language: English Journal: Trends Genet Journal subject: Genetics Year: 2020 Document Type: Article Affiliation country: J.tig.2020.08.003

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Polymorphism, Genetic / Serine Endopeptidases / Coronavirus Infections / Peptidyl-Dipeptidase A / ADAM17 Protein / Betacoronavirus Type of study: Experimental Studies Limits: Humans Language: English Journal: Trends Genet Journal subject: Genetics Year: 2020 Document Type: Article Affiliation country: J.tig.2020.08.003