Your browser doesn't support javascript.
Lactoferrin as potential preventative and adjunct treatment for COVID-19.
Chang, Raymond; Ng, Tzi Bun; Sun, Wei-Zen.
  • Chang R; Institute of East-West Medicine, 102 E 30th Street, New York, NY 10016, USA. Electronic address: chang@meridianmedical.org.
  • Ng TB; Chinese University of Hong Kong, Shatin, N.T., Hong Kong.
  • Sun WZ; Institute of East-West Medicine, 102 E 30th Street, New York, NY 10016, USA; National Taiwan University Hospital, 7 Chung Shan S. Road., Taipei, Taiwan.
Int J Antimicrob Agents ; 56(3): 106118, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-704750
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic is rapidly advancing across the globe despite drastic public and personal health measures. Antivirals and nutritional supplements have been proposed as potentially useful against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus that causes COVID-19, but few have been clinically established. Lactoferrin (Lf) is a naturally occurring, non-toxic glycoprotein that is orally available as a nutritional supplement and has established in vitro antiviral efficacy against a wide range of viruses, including SARS-CoV, a closely related coronavirus to SARS-CoV-2. Furthermore, Lf possesses unique immunomodulatory and anti-inflammatory effects that may be especially relevant to the pathophysiology of severe COVID-19 cases. Here we review the underlying biological mechanisms of Lf as an antiviral and immune regulator, and propose its unique potential as a preventative and adjunct treatment for COVID-19. We hope that further research and development of Lf nutritional supplementation would establish its role for COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Pandemics / Immunologic Factors / Lactoferrin / Anti-Inflammatory Agents Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Antimicrob Agents Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Coronavirus Infections / Pandemics / Immunologic Factors / Lactoferrin / Anti-Inflammatory Agents Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Int J Antimicrob Agents Year: 2020 Document Type: Article