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A physiological approach to understand the role of respiratory effort in the progression of lung injury in SARS-CoV-2 infection.
Cruces, Pablo; Retamal, Jaime; Hurtado, Daniel E; Erranz, Benjamín; Iturrieta, Pablo; González, Carlos; Díaz, Franco.
  • Cruces P; Escuela de Medicina Veterinaria, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.
  • Retamal J; Unidad de Paciente Crítico Pediátrico, Hospital El Carmen de Maipú, Santiago, Chile.
  • Hurtado DE; Departamento de Medicina Intensiva, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Erranz B; Instituto de Ingeniería Biológica y Médica, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Iturrieta P; Department of Structural and Geotechnical Engineering, School of Engineering Pontificia Universidad Católica de Chile, Santiago, Chile.
  • González C; Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile.
  • Díaz F; Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago, Chile.
Crit Care ; 24(1): 494, 2020 08 10.
Article in English | MEDLINE | ID: covidwho-704904
ABSTRACT
Deterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing.In addition, we discuss the current approach to respiratory support for COVID-19 under this point of view.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Work of Breathing / Coronavirus Infections / Disease Progression / Lung Injury Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Crit Care Year: 2020 Document Type: Article Affiliation country: S13054-020-03197-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Work of Breathing / Coronavirus Infections / Disease Progression / Lung Injury Type of study: Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Crit Care Year: 2020 Document Type: Article Affiliation country: S13054-020-03197-7