Your browser doesn't support javascript.
Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic.
Diamand, Romain; Ploussard, Guillaume; Roumiguié, Mathieu; Oderda, Marco; Benamran, Daniel; Fiard, Gaelle; Peltier, Alexandre; Simone, Giuseppe; Van Damme, Julien; Malavaud, Bernard; Iselin, Christophe; Descotes, Jean-Luc; Roche, Jean-Baptiste; Quackels, Thierry; Roumeguère, Thierry; Albisinni, Simone.
  • Diamand R; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. romain.diamand@erasme.ulb.ac.be.
  • Ploussard G; Urology Department, La Croix du Sud Hospital, Quint Fonsegrives, France.
  • Roumiguié M; Urology Department, CHU Toulouse, Toulouse, France.
  • Oderda M; Urology Department, Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
  • Benamran D; Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
  • Fiard G; Urology Department, CHU de Grenoble, Grenoble, France.
  • Peltier A; Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France.
  • Simone G; Urology Department, Jules Bordet Institute, Brussels, Belgium.
  • Van Damme J; Urology Department, IRCCS "Regina Elena" National Cancer Institute, Rome, Italy.
  • Malavaud B; Urology Department, University Clinics Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Iselin C; Urology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France.
  • Descotes JL; Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland.
  • Roche JB; Urology Department, CHU de Grenoble, Grenoble, France.
  • Quackels T; Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France.
  • Roumeguère T; Urology Department, Clinique Saint-Augustin, Bordeaux, France.
  • Albisinni S; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium.
World J Urol ; 39(6): 1789-1796, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-705039
ABSTRACT

PURPOSE:

The current COVID-19 pandemic is transforming our urologic practice and most urologic societies recommend to defer any surgical treatment for prostate cancer (PCa) patients. It is unclear whether a delay between diagnosis and surgical management (i.e., surgical delay) may have a detrimental effect on oncologic outcomes of PCa patients. The aim of the study was to assess the impact of surgical delay on oncologic outcomes.

METHODS:

Data of 926 men undergoing radical prostatectomy across Europe for intermediate and high-risk PCa according to EAU classification were identified. Multivariable analysis using binary logistic regression and Cox proportional hazard model tested association between surgical delay and upgrading on final pathology, lymph-node invasion (LNI), pathological locally advanced disease (pT3-4 and/or pN1), need for adjuvant therapy, and biochemical recurrence. Kaplan-Meier analysis was used to estimate BCR-free survival after surgery as a function of surgical delay using a 3 month cut-off.

RESULTS:

Median follow-up and surgical delay were 26 months (IQR 10-40) and 3 months (IQR 2-5), respectively. We did not find any significant association between surgical delay and oncologic outcomes when adjusted to pre- and post-operative variables. The lack of such association was observed across EAU risk categories.

CONCLUSION:

Delay of several months did not appear to adversely impact oncologic results for intermediate and high-risk PCa, and support an attitude of deferring surgery in line with the current recommendation of urologic societies.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Prostatectomy / Prostatic Neoplasms / Oncology Service, Hospital / Time-to-Treatment / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Humans / Male Country/Region as subject: Europa Language: English Journal: World J Urol Year: 2021 Document Type: Article Affiliation country: S00345-020-03402-w

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Prostatectomy / Prostatic Neoplasms / Oncology Service, Hospital / Time-to-Treatment / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Limits: Aged / Humans / Male Country/Region as subject: Europa Language: English Journal: World J Urol Year: 2021 Document Type: Article Affiliation country: S00345-020-03402-w