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The Strategic Alliance between Clinical and Molecular Science in the War against SARS-CoV-2, with the Rapid-Diagnostics Test as an Indispensable Weapon for Front Line Doctors.
Gaddi, Antonio Vittorino; Capello, Fabio; Aluigi, Leonardo; Antignani, Pier Luigi; Callegaro, Annapaola; Casu, Gavino; Cipolla, Enrico; Cipolla, Maurizio; Cosco, Lucio; Culzoni, Federico; Dentali, Francesco; Elexpuru-Zabaleta, Maria; Forbes-Hernandez, Tamara Y; Fragiacomo, Claudia; Giampieri, Francesca; Gnasso, Agostino; Mancini, Raffaele; Modena, Maria Grazia; Nichelatti, Michele; Paradiso, Angelo Virgilio; Ortasi, Pasquale; Savo, Maria Teresa; Tangianu, Flavio; Tempesta, Sergio; Voci, Tommaso Diego; Battino, Maurizio.
  • Gaddi AV; Society of Digital Health and Telemedicine, 40100 Bologna, Italy.
  • Capello F; International Study Center of Society of Telemedicine and Digital Health, 40100 Bologna, Italy.
  • Aluigi L; Villalba Private Hospital (GVM), 40100 Bologna, Italy.
  • Antignani PL; Vascular Centre, Nuova Villa Claudia, 00191 Rome, Italy.
  • Callegaro A; Department of Laboratory Medicine ASST-Papa Giovanni XXIII, 24127 Bergamo, Italy.
  • Casu G; Cardiology Dept. - ATS Sardegna ASSL, San Francesco Hospital, 08100 Nuoro, Italy.
  • Cipolla E; Alma Mater Studiorum Università di Bologna, 40126 Bologna, Italy.
  • Cipolla M; UCCP Catanzaro Lido, ASP Catanzaro; Calabria Society of Telemedicine-Regione Calabria, 88100 Catanzaro, Italy.
  • Cosco L; Infectious Disease Department., "Pugliese-Ciaccio" Hospital, 88100 Catanzaro, Italy.
  • Culzoni F; Culzoni Pharmacy, 20019 Milano, Italy.
  • Dentali F; Department of Clinical Medicine Insubria University Varese, 21100 Varese, Italy.
  • Elexpuru-Zabaleta M; Dipartimento di Scienze Cliniche e Molecolari, Facoltà di Medicina, Università Politecnica delle Marche, 60131 Ancona, Italy.
  • Forbes-Hernandez TY; Nutrition and Food Science Group, department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo-Vigo Campus, 32004 Vigo, Spain.
  • Fragiacomo C; Moncucco Clinic, 6900 Lugano, Switzerland.
  • Giampieri F; Nutrition and Food Science Group, department of Analytical and Food Chemistry, CITACA, CACTI, University of Vigo-Vigo Campus, 32004 Vigo, Spain.
  • Gnasso A; Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche, Università Politecnica delle Marche, Via Ranieri 65, 60130 Ancona, Italy.
  • Mancini R; College of Food Science and Technology, Northwest University, Xi'an 710069, China.
  • Modena MG; Department of Applied Medical Science, Magna Graecia University, 88100 Catanzaro, Italy.
  • Nichelatti M; Endocrinology and Diabetes Units, ASP, 88100 Catanzaro, Italy.
  • Paradiso AV; Surgical, Medical, Dental and Morphological Science Department with Transplantology, Oncological and Rigenerative Address, Modena e Reggio Emilia University, 41125 AOU Modena, Italy.
  • Ortasi P; Service of Statistics, Fondazione Malattie del Sangue Niguarda Hospital, 20162 Milano, Italy.
  • Savo MT; IRCCS-Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.
  • Tangianu F; Primary health care Department, ASL Area Vasta Romagna, National Medical Interdisciplinary Primary health care Ravenna-Forlì-Cesena, Society of Digital Health and Telemedicine, Emilia Romagna, 48121 Ravenna, Italy.
  • Tempesta S; Dipartimento di Medicina Interna, University of Florence, 50134 Firenze, Italy.
  • Voci TD; ASST Settelaghi Varese, Medical and Surgical Department, Insubria University, 21100 Varese, Italy.
  • Battino M; Technobios Prenatale Eurogenlab-Caravelli Group, Medical Genetics Laboratory, 40126 Bologna, Italy.
Int J Mol Sci ; 21(12)2020 Jun 22.
Article in English | MEDLINE | ID: covidwho-705276
ABSTRACT
Our work concerns the actual problem of spread of SARS- CoV-2 outbreak which requires fast and correct as possible answer. In current scenario, the need of rapid answer put away the imperative of proper methodology. We focus on the serogical immunoassay for diagnosis of Covid-19 as an important weapon not only for diagnostic purpose, but also for epidemiologic one. The right equilibrium between high speed, low cost and accuracy is obtained with easy-to-use decentralized point-of-care test as the colloidal gold-based immunochromatographic strip assay which detects IgM and IgG antibodies directed against SARS-CoV-2. As our aim is to evaluate the efficacy of Covid-19 rapid tests and of serological assays in real-life settings, we designed a research protocol aimed to establish how to use correctly these diagnostics, taking into account the different possible clinical and epidemiological scenarios.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Pandemics Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21124446

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Pandemics Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21124446