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Rethinking Gain-of-Function Experiments in the Context of the COVID-19 Pandemic.
mBio ; 11(4)2020 08 07.
Article in English | MEDLINE | ID: covidwho-705638
ABSTRACT
Proponents of the use of gain-of-function (GOF) experiments with pathogens with pandemic potential (PPP) have argued that such experiments are necessary because they reveal important facets of pathogenesis and can be performed safely. Opponents of GOF experiments with PPP have argued that the risks outweigh the knowledge gained. The COVID-19 pandemic demonstrates the vulnerability of human societies to a new PPP, while also validating some arguments of both camps, questioning others, and suggesting the need to rethink how we approach this class of experiments.
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Full text: Available Collection: International databases Database: MEDLINE Type: Article Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Gain of Function Mutation Subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Gain of Function Mutation Language: English Year: 2020

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Full text: Available Collection: International databases Database: MEDLINE Type: Article Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Gain of Function Mutation Subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus / Gain of Function Mutation Language: English Year: 2020