Your browser doesn't support javascript.
Antiplatelet/anticoagulant agents for preventing thrombosis events in patients with severe COVID-19: A protocol for systematic review and meta-analysis.
Li, Yiwei; Xu, Ying; Shi, Pengfei; Zhu, Ying; Hu, Wei; Chen, Can.
  • Li Y; Department of Intensive Care Unit.
  • Xu Y; Department of Hematology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, PR. China.
  • Shi P; Department of Hematology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, PR. China.
  • Zhu Y; Department of Intensive Care Unit.
  • Hu W; Department of Intensive Care Unit.
  • Chen C; Department of Hematology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine, Zhejiang, PR. China.
Medicine (Baltimore) ; 99(32): e21380, 2020 Aug 07.
Article in English | MEDLINE | ID: covidwho-706044
ABSTRACT

BACKGROUND:

On March 11, 2020, World Health Organization announced that severe acute respiratory syndrome coronavirus 2 caused COVID-19 was a global pandemic. COVID-19 is associated with venous thromboembolism including deep vein thrombosis and pulmonary embolism. To further identify the current role of antiplatelet/anticoagulant therapy in the prophylaxis and treatment of COVID-19 patients is important.

METHODS:

We will conduct a systematic review based on searches of major databases (eg, Pubmed, Web of Science, EMBASE, CENTRAL, MEDLINE, SCI-EXPANDED, CPCI-S, CBM, CNKI, and Wanfang Database) and clinical trial registries from inception to present without limitations of language and publication status. All published randomized control trials, quasi-randomized trials, retrospective and observational studies related to prophylactic antiplatelet/anticoagulant for severe COVID-19 will be included. Primary outcome includes incident acute thrombosis events. Second outcome is the incidence and severity of adverse effects. Full-text screening, data extraction and quality assessment will be conducted by 2 reviewers independently. The reporting quality, risk of bias, sensitivity analysis and subgroup analysis will be performed to ensure the reliability of our findings by other 2 researchers. The statistical analysis will be performed by RevMan V.5.3 software and Stata V.12.0 software.

RESULTS:

The result of this systematic review will provide valid advice and consultation for clinicians on the management of prophylactic antiplatelet/anticoagulant for severe COVID-19 patients.

CONCLUSION:

This systematic review will provide evidence for prophylactic antiplatelet/anticoagulant of severe COVID-19 patients. PROSPERO REGISTRATION CRD42020186928.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Platelet Aggregation Inhibitors / Hospital Mortality / Coronavirus Infections / Pandemics / Anticoagulants Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Medicine (Baltimore) Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Platelet Aggregation Inhibitors / Hospital Mortality / Coronavirus Infections / Pandemics / Anticoagulants Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Medicine (Baltimore) Year: 2020 Document Type: Article