Macrophage activation syndrome as an unusual presentation of paucisymptomatic severe acute respiratory syndrome coronavirus 2 infection: A case report.
Medicine (Baltimore)
; 99(32): e21570, 2020 Aug 07.
Article
in English
| MEDLINE | ID: covidwho-706114
ABSTRACT
RATIONALE Macrophage activation syndrome (MAS) is a rare life-threatening condition characterized by cytokine-mediated tissue injury and multiorgan dysfunction. PATIENT CONCERNS We describe the unique case of young man who developed MAS as the sole manifestation of an otherwise paucisymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. DIAGNOSES Clinical and biological criteria led to the diagnosis of MAS; cytokine profile was highly suggestive reverse transcription polymerase chain reaction for SARS-CoV-2 in nasopharyngeal swabs was negative, but serum anti-SARS-CoV-2 immunoglobulin A and immunoglobulin G resulted positive leading to the diagnosis of SARS-CoV-2 infection. INTERVENTIONS:
The patient was treated with empiric antibiotic and hydroxychloroquine.OUTCOMES:
Clinical improvement ensued. At follow-up, the patient is well. LESSON SARS-CoV-2 infection may trigger develop life-threatening complications, like MAS. This can be independent from coronavirus disease 2019 gravity.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Ceftriaxone
/
Coronavirus Infections
/
Macrophage Activation Syndrome
/
Hospitalization
/
Hydroxychloroquine
Type of study:
Case report
/
Cohort study
/
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Medicine (Baltimore)
Year:
2020
Document Type:
Article
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