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Macrophage activation syndrome as an unusual presentation of paucisymptomatic severe acute respiratory syndrome coronavirus 2 infection: A case report.
Lolachi, Sanaz; Morin, Sarah; Coen, Matteo; Samii, Kaveh; Calmy, Alexandra; Serratrice, Jacques.
  • Lolachi S; Division of General Internal Medicine, Department of Medicine.
  • Morin S; Hematology Division, Department of Oncology, Geneva University Hospitals.
  • Coen M; Division of General Internal Medicine, Department of Medicine.
  • Samii K; University of Geneva, Faculty of Medicine, Unit of Development and Research in Medical Education (UDREM).
  • Calmy A; Hematology Division, Department of Oncology, Geneva University Hospitals.
  • Serratrice J; Laboratory of Virology and Division of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland.
Medicine (Baltimore) ; 99(32): e21570, 2020 Aug 07.
Article in English | MEDLINE | ID: covidwho-706114
ABSTRACT
RATIONALE Macrophage activation syndrome (MAS) is a rare life-threatening condition characterized by cytokine-mediated tissue injury and multiorgan dysfunction. PATIENT CONCERNS We describe the unique case of young man who developed MAS as the sole manifestation of an otherwise paucisymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. DIAGNOSES Clinical and biological criteria led to the diagnosis of MAS; cytokine profile was highly suggestive reverse transcription polymerase chain reaction for SARS-CoV-2 in nasopharyngeal swabs was negative, but serum anti-SARS-CoV-2 immunoglobulin A and immunoglobulin G resulted positive leading to the diagnosis of SARS-CoV-2 infection.

INTERVENTIONS:

The patient was treated with empiric antibiotic and hydroxychloroquine.

OUTCOMES:

Clinical improvement ensued. At follow-up, the patient is well. LESSON SARS-CoV-2 infection may trigger develop life-threatening complications, like MAS. This can be independent from coronavirus disease 2019 gravity.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Ceftriaxone / Coronavirus Infections / Macrophage Activation Syndrome / Hospitalization / Hydroxychloroquine Type of study: Case report / Cohort study / Diagnostic study / Prognostic study Limits: Adolescent / Humans / Male Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Ceftriaxone / Coronavirus Infections / Macrophage Activation Syndrome / Hospitalization / Hydroxychloroquine Type of study: Case report / Cohort study / Diagnostic study / Prognostic study Limits: Adolescent / Humans / Male Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2020 Document Type: Article