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Genome evolution of SARS-CoV-2 and its virological characteristics.
Nakagawa, So; Miyazawa, Takayuki.
  • Nakagawa S; Molecular Life Science, School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193 Japan.
  • Miyazawa T; Institute of Medical Sciences, Tokai University, Kanagawa, Japan.
Inflamm Regen ; 40: 17, 2020.
Article in English | MEDLINE | ID: covidwho-706440
ABSTRACT
Coronavirus disease of 2019 (COVID-19), which originated in China in 2019, shows mild cold and pneumonia symptoms that can occasionally worsen and result in deaths. SARS-CoV-2 was reported to be the causative agent of the disease and was identified as being similar to SARS-CoV, a causative agent of SARS in 2003. In this review, we described the phylogeny of SARS-CoV-2, covering various related studies, in particular, focusing on viruses obtained from horseshoe bats and pangolins that belong to Sarbecovirus, a subgenus of Betacoronavirus. We also describe the virological characteristics of SARS-CoV-2 and compare them with other coronaviruses. More than 30,000 genome sequences of SARS-CoV-2 are available in the GISAID database as of May 28, 2020. Using the genome sequence data of closely related viruses, the genomic characteristics and evolution of SARS-CoV-2 were extensively studied. However, given the global prevalence of COVID-19 and the large number of associated deaths, further computational and experimental virological analyses are required to fully characterize SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Journal: Inflamm Regen Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study Language: English Journal: Inflamm Regen Year: 2020 Document Type: Article