Possible Targets and Therapies of SARS-CoV-2 Infection.
Mini Rev Med Chem
; 20(18): 1900-1907, 2020.
Article
in English
| MEDLINE | ID: covidwho-706996
ABSTRACT
The global spread of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) that causes COVID-19 has become a source of grave medical and socioeconomic concern to human society. Since its first appearance in the Wuhan region of China in December 2019, the most effective measures of managing the spread of SARS-CoV-2 infection have been social distancing and lockdown of human activity; the level of which has not been seen in our generations. Effective control of the viral infection and COVID-19 will ultimately depend on the development of either a vaccine or therapeutic agents. This article highlights the progresses made so far in these strategies by assessing key targets associated with the viral replication cycle. The key viral proteins and enzymes that could be targeted by new and repurposed drugs are discussed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA-Dependent RNA Polymerase
/
RNA Helicases
/
Coronavirus 3C Proteases
/
COVID-19
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Mini Rev Med Chem
Journal subject:
Chemistry
Year:
2020
Document Type:
Article
Affiliation country:
1389557520666200807131855
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