COVID-19 in pregnancy: Placental and neonatal involvement.
Am J Reprod Immunol
; 84(5): e13306, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-708944
ABSTRACT
Since December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 12 million infections and more than 550 000 deaths.1 Morbidity and mortality appear partly due to host inflammatory response.2 Despite rapid, global research, the effect of SARS-CoV-2 on the developing fetus remains unclear. Case reports indicate that vertical transmission is uncommon; however, there is evidence that placental and fetal infection can occur.3-7 Placentas from infected patients show inflammatory, thrombotic, and vascular changes that have been found in other inflammatory conditions.8,9 This suggests that the inflammatory nature of SARS-CoV-2 infection during pregnancy could cause adverse obstetric and neonatal events. Exposure to intrauterine inflammation and placental changes could also potentially result in long-term, multisystemic defects in exposed infants. This review will summarize the known literature on the placenta in SARS-CoV-2 infection, evidence of vertical transmission, and possible outcomes of prenatal exposure to the virus.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Placenta
/
Pregnancy Complications, Infectious
/
Prenatal Exposure Delayed Effects
/
Pregnancy
/
SARS-CoV-2
/
COVID-19
Limits:
Female
/
Humans
/
Infant, Newborn
Language:
English
Journal:
Am J Reprod Immunol
Year:
2020
Document Type:
Article
Affiliation country:
Aji.13306
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