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Efficacy and safety of disinfectants for decontamination of N95 and SN95 filtering facepiece respirators: a systematic review.
O'Hearn, K; Gertsman, S; Webster, R; Tsampalieros, A; Ng, R; Gibson, J; Sampson, M; Sikora, L; McNally, J D.
  • O'Hearn K; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada. Electronic address: kohearn@cheo.on.ca.
  • Gertsman S; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
  • Webster R; Clinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
  • Tsampalieros A; Clinical Research Unit, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
  • Ng R; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
  • Gibson J; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada.
  • Sampson M; Library Services, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
  • Sikora L; Health Sciences Library, University of Ottawa, Ottawa, Ontario, Canada.
  • McNally JD; Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada; Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada. Electronic address: dmcnally@cheo.on.ca.
J Hosp Infect ; 106(3): 504-521, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-709227
Semantic information from SemMedBD (by NLM)
1. Mechanical Ventilator TREATS Health Personnel
Subject
Mechanical Ventilator
Predicate
TREATS
Object
Health Personnel
2. Airflow AFFECTS Viral Pathogenesis
Subject
Airflow
Predicate
AFFECTS
Object
Viral Pathogenesis
3. contextual factors PROCESS_OF World
Subject
contextual factors
Predicate
PROCESS_OF
Object
World
4. hydrogen peroxide AFFECTS Seizures
Subject
hydrogen peroxide
Predicate
AFFECTS
Object
Seizures
5. hydrogen peroxide NEG_INTERACTS_WITH VPS51 gene|VPS51
Subject
hydrogen peroxide
Predicate
NEG_INTERACTS_WITH
Object
VPS51 gene|VPS51
6. Mechanical Ventilator TREATS Health Personnel
Subject
Mechanical Ventilator
Predicate
TREATS
Object
Health Personnel
7. Airflow AFFECTS Viral Pathogenesis
Subject
Airflow
Predicate
AFFECTS
Object
Viral Pathogenesis
8. contextual factors PROCESS_OF World
Subject
contextual factors
Predicate
PROCESS_OF
Object
World
9. hydrogen peroxide AFFECTS Seizures
Subject
hydrogen peroxide
Predicate
AFFECTS
Object
Seizures
10. hydrogen peroxide NEG_INTERACTS_WITH VPS51 gene|VPS51
Subject
hydrogen peroxide
Predicate
NEG_INTERACTS_WITH
Object
VPS51 gene|VPS51
ABSTRACT

BACKGROUND:

Decontaminating and reusing filtering facepiece respirators (FFRs) for healthcare workers is a potential solution to address inadequate FFR supply during a global pandemic.

AIM:

The objective of this review was to synthesize existing data on the effectiveness and safety of using chemical disinfectants to decontaminate N95 FFRs.

METHODS:

A systematic review was conducted on disinfectants to decontaminate N95 FFRs using Embase, Medline, Global Health, Google Scholar, WHO feed, and MedRxiv. Two reviewers independently determined study eligibility and extracted predefined data fields. Original research reporting on N95 FFR function, decontamination, safety, or FFR fit following decontamination with a disinfectant was included. FINDINGS AND

CONCLUSION:

A single cycle of vaporized hydrogen peroxide (H2O2) successfully removes viral pathogens without affecting airflow resistance or fit, and maintains an initial filter penetration of <5%, with little change in FFR appearance. Residual hydrogen peroxide levels following decontamination were within safe limits. More than one decontamination cycle of vaporized H2O2 may be possible but further information is required on how multiple cycles would affect FFR fit in a real-world setting before the upper limit can be established. Although immersion in liquid H2O2 does not appear to adversely affect FFR function, there is no available data on its ability to remove infectious pathogens from FFRs or its impact on FFR fit. Sodium hypochlorite, ethanol, isopropyl alcohol, and ethylene oxide are not recommended due to safety concerns or negative effects on FFR function.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Protective Devices / Sodium Hypochlorite / Decontamination / Equipment Reuse / Coronavirus Infections / Disinfectants / Hydrogen Peroxide Type of study: Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: J Hosp Infect Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Protective Devices / Sodium Hypochlorite / Decontamination / Equipment Reuse / Coronavirus Infections / Disinfectants / Hydrogen Peroxide Type of study: Reviews / Systematic review/Meta Analysis Limits: Humans Language: English Journal: J Hosp Infect Year: 2020 Document Type: Article