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The microbial coinfection in COVID-19.
Chen, Xi; Liao, Binyou; Cheng, Lei; Peng, Xian; Xu, Xin; Li, Yuqing; Hu, Tao; Li, Jiyao; Zhou, Xuedong; Ren, Biao.
  • Chen X; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
  • Liao B; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Cheng L; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
  • Peng X; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
  • Xu X; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Li Y; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
  • Hu T; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
  • Li J; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.
  • Zhou X; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
  • Ren B; State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, Sichuan University, NO. 14, 3rd Section of Ren Min Nan Rd. Chengdu, Sichuan, 610041, China.
Appl Microbiol Biotechnol ; 104(18): 7777-7785, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-709732
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel ß-coronavirus, is the main pathogenic agent of the rapidly spreading pneumonia called coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects much more people, especially the elder population, around the world than other coronavirus, such as SARS-CoV and MERS-CoV, which is challenging current global public health system. Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. We summarize the coinfection of virus, bacteria and fungi with SARS-CoV-2, their effects on COVID-19, the reasons of coinfection, and the diagnosis to emphasize the importance of microbial coinfection in COVID-19. KEY POINTS • Microbial coinfection is a nonnegligible factor in COVID-19. • Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. • Different virus, bacteria, and fungi contributed to the coinfection with SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Bacterial Infections / Virus Diseases / Coronavirus Infections / Pandemics / Cytokine Release Syndrome / Lymphopenia / Mycoses Type of study: Observational study / Prognostic study Language: English Journal: Appl Microbiol Biotechnol Year: 2020 Document Type: Article Affiliation country: S00253-020-10814-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Bacterial Infections / Virus Diseases / Coronavirus Infections / Pandemics / Cytokine Release Syndrome / Lymphopenia / Mycoses Type of study: Observational study / Prognostic study Language: English Journal: Appl Microbiol Biotechnol Year: 2020 Document Type: Article Affiliation country: S00253-020-10814-6