The microbial coinfection in COVID-19.
Appl Microbiol Biotechnol
; 104(18): 7777-7785, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-709732
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel ß-coronavirus, is the main pathogenic agent of the rapidly spreading pneumonia called coronavirus disease 2019 (COVID-19). SARS-CoV-2 infects much more people, especially the elder population, around the world than other coronavirus, such as SARS-CoV and MERS-CoV, which is challenging current global public health system. Beyond the pathogenesis of SARS-CoV-2, microbial coinfection plays an important role in the occurrence and development of SARS-CoV-2 infection by raising the difficulties of diagnosis, treatment, prognosis of COVID-19, and even increasing the disease symptom and mortality. We summarize the coinfection of virus, bacteria and fungi with SARS-CoV-2, their effects on COVID-19, the reasons of coinfection, and the diagnosis to emphasize the importance of microbial coinfection in COVID-19. KEY POINTS ⢠Microbial coinfection is a nonnegligible factor in COVID-19. ⢠Microbial coinfection exacerbates the processes of the occurrence, development and prognosis of COVID-19, and the difficulties of clinical diagnosis and treatment. ⢠Different virus, bacteria, and fungi contributed to the coinfection with SARS-CoV-2.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Bacterial Infections
/
Virus Diseases
/
Coronavirus Infections
/
Pandemics
/
Cytokine Release Syndrome
/
Lymphopenia
/
Mycoses
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Appl Microbiol Biotechnol
Year:
2020
Document Type:
Article
Affiliation country:
S00253-020-10814-6
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