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Pharmacokinetic Basis of the Hydroxychloroquine Response in COVID-19: Implications for Therapy and Prevention.
Tarek, Mohammad; Savarino, Andrea.
  • Tarek M; Bioinformatics Department, Armed Forces College of Medicine (AFCM), Cairo, Egypt.
  • Savarino A; Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy. andrea.savarino@iss.it.
Eur J Drug Metab Pharmacokinet ; 45(6): 715-723, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-709935
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ABSTRACT
BACKGROUND AND

OBJECTIVES:

Chloroquine/hydroxychloroquine has recently been the subject of intense debate regarding its potential antiviral activity against SARS-Cov-2, the etiologic agent of COVID-19. Some report possible curative effects; others do not. Therefore, the objective of this study was to simulate possible scenarios of response to hydroxychloroquine in COVID-19 patients using mathematical modeling.

METHODS:

To shed some light on this controversial topic, we simulated hydroxychloroquine-based interventions on virus/host cell dynamics using a basic system of previously published differential equations. Mathematical modeling was implemented using Python programming language v 3.7.

RESULTS:

According to mathematical modeling, hydroxychloroquine may have an impact on the amplitude of the viral load peak and viral clearance if the drug is administered early enough (i.e., when the virus is still confined within the pharyngeal cavity). The effects of chloroquine/hydroxychloroquine may be fully explained only when also considering the capacity of this drug to increase the death rate of SARS-CoV-2-infected cells, in this case by enhancing the cell-mediated immune response.

CONCLUSIONS:

These considerations may not only be applied to chloroquine/hydroxychloroquine but may have more general implications for development of anti-COVID-19 combination therapies and prevention strategies through an increased death rate of the infected cells.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Hydroxychloroquine Type of study: Etiology study / Observational study Limits: Humans Language: English Journal: Eur J Drug Metab Pharmacokinet Year: 2020 Document Type: Article Affiliation country: S13318-020-00640-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Hydroxychloroquine Type of study: Etiology study / Observational study Limits: Humans Language: English Journal: Eur J Drug Metab Pharmacokinet Year: 2020 Document Type: Article Affiliation country: S13318-020-00640-6