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Towards Neuro-CoViD-19.
Chiappelli, Francesco.
  • Chiappelli F; UCLA Center for the Health Sciences, Los Angeles, California, USA.
Bioinformation ; 16(4): 288-292, 2020.
Article in English | MEDLINE | ID: covidwho-2313646
ABSTRACT
CoViD-19 is the current pandemic caused by the Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2). Infection by SARS-CoV-2 occurs via the binding of its S protein to the angiotensin-converting enzyme-2 receptor (ACE2-R). S binding to ACE2-R leads to a drop in ACE2, a homolog of angiotensin converting enzyme (ACE). In the central nervous system (CNS), ACE mediates neuroinflammation, neurodegeneration and neurotoxicity responsible for several CNS disorders. ACE2 counteracts the damaging effects of ACE on CNS neurons. SARS-CoV-2 can directly access the CNS via the circulation or via cranial nerve I and the olfactory bulb. Inactivation of ACE2 following binding of SARS-CoV-2 S protein to ACE2-R in situ might blunt ACE2-moderating effects upon ACE CNS neurotoxicity and neurodegeneration. Here, we propose a neurobiological mechanism directly involving SARS-CoV-2 binding to ACE2-R in the etiology of putative Neuro-CoViD-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study Language: English Journal: Bioinformation Year: 2020 Document Type: Article Affiliation country: 97320630016288

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study Language: English Journal: Bioinformation Year: 2020 Document Type: Article Affiliation country: 97320630016288