Your browser doesn't support javascript.
H2S as a potential defense against COVID-19?
Yang, Guangdong.
  • Yang G; Cardiovascular and Metabolic Research Unit, Laurentian University, Sudbury, Ontario, Canada.
Am J Physiol Cell Physiol ; 319(2): C244-C249, 2020 08 01.
Article in English | MEDLINE | ID: covidwho-889936
ABSTRACT
The outbreak of COVID-19 pneumonia caused by a new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is posing a global health emergency and has led to more than 380,000 deaths worldwide. The cell entry of SARS-CoV-2 depends on two host proteins angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). There is currently no vaccine available and also no effective drug for the treatment of COVID-19. Hydrogen sulfide (H2S) as a novel gasotransmitter has been shown to protect against lung damage via its anti-inflammation, antioxidative stress, antiviral, prosurvival, and antiaging effects. In light of the research advances on H2S signaling in biology and medicine, this review proposed H2S as a potential defense against COVID-19. It is suggested that H2S may block SARS-CoV-2 entry into host cells by interfering with ACE2 and TMPRSS2, inhibit SARS-CoV-2 replication by attenuating virus assembly/release, and protect SARS-CoV-2-induced lung damage by suppressing immune response and inflammation development. Preclinical studies and clinical trials with slow-releasing H2S donor(s) or the activators of endogenous H2S-generating enzymes should be considered as a preventative treatment or therapy for COVID-19.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Virus Replication / Coronavirus Infections / Virus Internalization / Betacoronavirus / Hydrogen Sulfide Type of study: Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Am J Physiol Cell Physiol Journal subject: Physiology Year: 2020 Document Type: Article Affiliation country: Ajpcell.00187.2020

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Virus Replication / Coronavirus Infections / Virus Internalization / Betacoronavirus / Hydrogen Sulfide Type of study: Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Am J Physiol Cell Physiol Journal subject: Physiology Year: 2020 Document Type: Article Affiliation country: Ajpcell.00187.2020