Epstein-Barr Virus Versus Novel Coronavirus-Induced Hemophagocytic Lymphohistocytosis: The Uncharted Waters.
J Investig Med High Impact Case Rep
; 8: 2324709620950107, 2020.
Article
in English
| MEDLINE | ID: covidwho-712896
ABSTRACT
Hemophagocytic lymphohistocytosis (HLH) is a hyperinflammatory syndrome characterized by fever, hepatosplenomegaly, and pancytopenia. It may be associated with genetic mutations or viral/bacterial infections, most commonly Epstein-Barr virus (EBV) and cytomegalovirus. As for the novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), also known as COVID-19 (coronavirus disease-2019), the cytokine storm it triggers can theoretically lead to syndromes similar to HLH. In this article, we report a case of a 28-year-old female who presented with high-grade fevers, found to have both SARS-CoV-2 and EBV infections, and eventually began to show signs of early HLH. To our knowledge, this is the first case reported in literature that raises the possibility of SARS-CoV-2-related HLH development.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Infections
/
Lymphohistiocytosis, Hemophagocytic
/
Betacoronavirus
Type of study:
Case report
/
Diagnostic study
Topics:
Long Covid
/
Variants
Limits:
Adult
/
Female
/
Humans
Language:
English
Journal:
J Investig Med High Impact Case Rep
Year:
2020
Document Type:
Article
Affiliation country:
2324709620950107
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