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Pathophysiology of COVID-19: Mechanisms Underlying Disease Severity and Progression.
Bohn, Mary Kathryn; Hall, Alexandra; Sepiashvili, Lusia; Jung, Benjamin; Steele, Shannon; Adeli, Khosrow.
  • Bohn MK; Molecular Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Hall A; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Sepiashvili L; Molecular Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Jung B; Molecular Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
  • Steele S; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
  • Adeli K; Molecular Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.
Physiology (Bethesda) ; 35(5): 288-301, 2020 09 01.
Article in English | MEDLINE | ID: covidwho-713009
ABSTRACT
The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and laboratory characteristics of COVID-19 patients have been well characterized, the pathophysiological mechanisms underlying disease severity and progression remain unclear. This review highlights key mechanisms that have been proposed to contribute to COVID-19 progression from viral entry to multisystem organ failure, as well as the central role of the immune response in successful viral clearance or progression to death.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: Physiology (Bethesda) Journal subject: Physiology Year: 2020 Document Type: Article Affiliation country: Physiol.00019.2020

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: Physiology (Bethesda) Journal subject: Physiology Year: 2020 Document Type: Article Affiliation country: Physiol.00019.2020