Your browser doesn't support javascript.
Various interferon (IFN)-inducible transmembrane (IFITM) proteins for COVID-19, is there a role for the combination of mycophenolic acid and interferon?
Dowran, Razieh; Nabavi, Seyed Fazel; Habtemariam, Solomon; Banach, Maciej; Shahmohamadnejad, Shiva; Cismaru, Cosmin Andrei; Berindan-Neagoe, Ioana; Sahebnasagh, Adeleh; Nabavi, Seyed Mohammad.
  • Dowran R; Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
  • Nabavi SF; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran.
  • Habtemariam S; Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Chatham-Maritime, ME4 4TB Kent, UK.
  • Banach M; Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland; Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
  • Shahmohamadnejad S; Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Cismaru CA; Research Center for Functional Genomics, Biomedicine and Translational Medicine, The "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Functional Sciences, Immunology and Allergology, The "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Rom
  • Berindan-Neagoe I; Research Center for Functional Genomics, Biomedicine and Translational Medicine, The "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Functional Genomics and Experimental Pathology, The Oncology Institute "Prof. Dr. Ion Chiricuta", Cluj-Napoca, Romania.
  • Sahebnasagh A; Clinical Research Center, Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran.
  • Nabavi SM; Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Nabavi208@gmail.com.
Biochimie ; 177: 50-52, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-713261
ABSTRACT
Various interferon (IFN)-inducible transmembrane (IFITM) proteins are known to be expressed in human tissues though only IFITM 1-3 are inducible by IFN. Numerous studies have shown that activation of IFITM3 could suppress infection by influenza and coronaviruses such as the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). In view of the potential application of IFITM proteins' induction to target SARS-CoV-2 infection that causes COVID-19, this article layout insights into the known antiviral mechanisms and therapeutic agents related to IFITM. Blocking viral entry through various mechanisms and the potential application of the FDA approved immunosuppressant agent, mycophenolic acid, as inducer of IFITM3 are among those discussed.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interferons / RNA-Binding Proteins / Coronavirus Infections / Betacoronavirus / Membrane Proteins / Mycophenolic Acid Limits: Animals / Humans Language: English Journal: Biochimie Year: 2020 Document Type: Article Affiliation country: J.biochi.2020.08.006

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interferons / RNA-Binding Proteins / Coronavirus Infections / Betacoronavirus / Membrane Proteins / Mycophenolic Acid Limits: Animals / Humans Language: English Journal: Biochimie Year: 2020 Document Type: Article Affiliation country: J.biochi.2020.08.006