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Serum Protein Profiling Reveals a Landscape of Inflammation and Immune Signaling in Early-stage COVID-19 Infection.
Hou, Xin; Zhang, Xiaomei; Wu, Xian; Lu, Minya; Wang, Dan; Xu, Meng; Wang, Hongye; Liang, Te; Dai, Jiayu; Duan, Hu; Xu, Yingchun; Yu, Xiaobo; Li, Yongzhe.
  • Hou X; Department of Clinical Laboratory & Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
  • Zhang X; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China.
  • Wu X; Department of Clinical Laboratory & Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
  • Lu M; Department of Clinical Laboratory & Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.
  • Wang D; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China.
  • Xu M; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China.
  • Wang H; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China.
  • Liang T; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China.
  • Dai J; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China.
  • Duan H; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China.
  • Xu Y; Department of Clinical Laboratory & Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. Electronic address: xycpumch@139.c
  • Yu X; State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing, China. Electronic address: yuxiaobo@mail.ncpsb.org.
  • Li Y; Department of Clinical Laboratory & Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China. Electronic address: yongzhelipumch
Mol Cell Proteomics ; 19(11): 1749-1759, 2020 11.
Article in English | MEDLINE | ID: covidwho-713514
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ABSTRACT
Coronavirus disease 2019 (COVID-19) is a highly contagious infection and threating the human lives in the world. The elevation of cytokines in blood is crucial to induce cytokine storm and immunosuppression in the transition of severity in COVID-19 patients. However, the comprehensive changes of serum proteins in COVID-19 patients throughout the SARS-CoV-2 infection is unknown. In this work, we developed a high-density antibody microarray and performed an in-depth proteomics analysis of serum samples collected from early COVID-19 (n = 15) and influenza (n = 13) patients. We identified a large set of differentially expressed proteins (n = 132) that participate in a landscape of inflammation and immune signaling related to the SARS-CoV-2 infection. Furthermore, the significant correlations of neutrophil and lymphocyte with the CCL2 and CXCL10 mediated cytokine signaling pathways was identified. These information are valuable for the understanding of COVID-19 pathogenesis, identification of biomarkers and development of the optimal anti-inflammation therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Proteins / Coronavirus Infections / Cough / Influenza, Human / Fever / Myalgia / Cytokine Release Syndrome / Headache Type of study: Prognostic study Language: English Journal: Mol Cell Proteomics Journal subject: Molecular Biology / Biochemistry Year: 2020 Document Type: Article Affiliation country: Mcp.RP120.002128

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Blood Proteins / Coronavirus Infections / Cough / Influenza, Human / Fever / Myalgia / Cytokine Release Syndrome / Headache Type of study: Prognostic study Language: English Journal: Mol Cell Proteomics Journal subject: Molecular Biology / Biochemistry Year: 2020 Document Type: Article Affiliation country: Mcp.RP120.002128